神经药理学报››2017,Vol. 7››Issue (1): 53-64.DOI:10.3969/j.issn.2095-1396.2017.01.007
• 综述 •上一篇
孙志华，罗素兰
出版日期:2017-02-26发布日期:2017-12-01通讯作者:罗素兰，女，海南大学长江学者特聘教授，博士，博士生导师；研究方向：海洋药物与生物技术；Tel：+86-089866289538，E-mail：luosulan2003@163.com作者简介:孙志华，男，博士研究生；研究方向：芋螺毒素抗癌研究；E-mail：zhihuasun918@163.com基金资助:
国家自然科学基金项目（No.81420108028），长江学者和创新团队发展计划（No.IRT_15R15），海南省普通高等学校研究生创新科研课题（No.Hyb2016-08）
SUN Zhi-hua，LUO Su-lan
Online:2017-02-26Published:2017-12-01Contact:罗素兰，女，海南大学长江学者特聘教授，博士，博士生导师；研究方向：海洋药物与生物技术；Tel：+86-089866289538，E-mail：luosulan2003@163.comAbout author:孙志华，男，博士研究生；研究方向：芋螺毒素抗癌研究；E-mail：zhihuasun918@163.comSupported by:
国家自然科学基金项目（No.81420108028），长江学者和创新团队发展计划（No.IRT_15R15），海南省普通高等学校研究生创新科研课题（No.Hyb2016-08）
摘要：烟碱型乙酰胆碱受体（nicotinic acetylcholine receptors，nAChRs）属于配体门控离子通道，广泛分布于中枢神经系统、周围神经系统和肌肉组织非神经系统中，不同的亚基组成形式决定了其对激动剂或拮抗剂不同的亲和力。近期的研究表明，nAChRs 与神经痛、帕金森病、阿尔茨海默病（老年痴呆症）以及小细胞肺癌、乳腺癌、宫颈癌等多种疾病的病理进程息息相关。该文就几种疾病与nAChRs 结构、功能及其二者相关性进行综述，并重点阐述 nAChRs 介导的 α- 芋螺毒素抗肿瘤研究进展，以期为芋螺毒素的抗肿瘤药物的研发提供理论依据。
中图分类号:
孙志华, 罗素兰.烟碱型乙酰胆碱受体及其相关疾病[J]. 神经药理学报, 2017, 7(1): 53-64.
SUN Zhi-hua, LUO Su-lan.Nicotinic Acetylcholine Receptors and Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2017, 7(1): 53-64.
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