神经药理学报››2017,Vol. 7››Issue (4): 53-64.DOI:10.3969/j.issn.2095-1396.2017.04.008
• 综述 •上一篇
田由，王雪，艾静
出版日期:2017-08-26发布日期:2017-12-01通讯作者:艾静，女，博士，教授，博士生导师；研究方向：神经药理学；Tel：+86-0451-86671354，E-mail：azhrbmu@126.com作者简介:田由，女，硕士研究生；研究方向：神经药理学；E-mail：13225779116@163.com基金资助:
国家自然科学基金资助项目（No.81271207，No.81471115，No.81671052）
TIAN You，WANG Xue，AI Jing
Online:2017-08-26Published:2017-12-01Contact:艾静，女，博士，教授，博士生导师；研究方向：神经药理学；Tel：+86-0451-86671354，E-mail：azhrbmu@126.comAbout author:田由，女，硕士研究生；研究方向：神经药理学；E-mail：13225779116@163.comSupported by:
国家自然科学基金资助项目（No.81271207，No.81471115，No.81671052）
摘要：细胞外老年斑的沉积和细胞内神经纤维缠结被认为是阿尔茨海默病（Alzheimer’s disease，AD）典型的病理改变。基底前脑胆碱能神经元（basal forebrain cholinergic neurons，BFCNs）功能异常导致的海马乙酰胆碱（acetylcholine，ACh）功能下降也被认为是AD 发生的主要特征。该文介绍了ACh 突触传递过程、BFCNs 投射系统、BFCNs 在调节认知功能中的作用以及BFCNs 功能异常在AD 中的作用和近期的研究进展。
中图分类号:
田由，王雪，艾静.基底前脑胆碱能神经元功能异常在阿尔茨海默病中的作用相关研究进展[J]. 神经药理学报, 2017, 7(4): 53-64.
TIAN You，WANG Xue，AI Jing. Research Progress of Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(4): 53-64.
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