任婧，张丹参
出版日期:2017-10-26发布日期:2017-12-01通讯作者:张丹参，女，博士生导师；研究方向：神经药理学；E-mail：zhangds2011@126.com作者简介:任婧，女，硕士研究生；研究方向：神经药理学；E-mail：18333156063@163.com基金资助:
REN Jing，ZHANG Dan-shen
Online:2017-10-26Published:2017-12-01Contact:张丹参，女，博士生导师；研究方向：神经药理学；E-mail：zhangds2011@126.comAbout author:任婧，女，硕士研究生；研究方向：神经药理学；E-mail：18333156063@163.comSupported by:
摘要：
姜黄素是从姜科植物姜黄属姜黄、莪术、郁金等根茎中提取到的一种天然黄色小分子植物酸性多酚，是中药姜黄的主要活性成分。姜黄素具有抗氧化、抗炎，神经保护作用以及调节神经递质和细胞内信号传导途径等药理作用，还可以增强神经可塑性，增加神经再生，这些药理作用使得姜黄素在神经退行性疾病以及情绪障碍
方面的疾病中发挥了重要作用，目前可以作为阿尔茨海默病、帕金森病、抑郁症、脑缺血再灌注损伤等中枢神经系统疾病的控制与治疗的药物；姜黄素还有抑制肿瘤细胞增殖作用、临床也可用于脑胶质瘤的治疗和预防，姜黄素具有较高有效性和安全性，毒副作用小。但姜黄素难溶于水，生物利用度低等问题限制了姜黄素在临床用药上的发展前景，可以通过改变姜黄素的给药方式和剂型来弥补这种缺点。目前姜黄素可以制备脂质体、纳米粒、微球、胶束、微乳等剂型来进行不同方式的给 药，用来改善其亲水性，提高生物利用度。
中图分类号:
任婧，张丹参.姜黄素纳米剂型及在神经系统疾病中应用的研究进展[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2017.05.008.
REN Jing，ZHANG Dan-shen.Research Progress of Curcumin in the Treatment of Nervous System Diseases[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2017.05.008.
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