刑媛，张楠 ，张炜，任雷鸣#br#
出版日期:2018-06-26发布日期:2018-11-16通讯作者:张炜，女，教授；研究方向：神经药理学；E-mail：weizhang@hebmu.edu.cn 任雷鸣，男，教授；研究方向：神经药理学、心血管药理学；E-mail：ren-leiming@263.net作者简介:邢媛，女，河北医科大学药理学博士研究生基金资助:
XING Yuan，ZHANG Nan，ZHANG Wei，REN Lei-ming
Online:2018-06-26Published:2018-11-16Contact:张炜，女，教授；研究方向：神经药理学；E-mail：weizhang@hebmu.edu.cn 任雷鸣，男，教授；研究方向：神经药理学、心血管药理学；E-mail：ren-leiming@263.netAbout author:邢媛，女，河北医科大学药理学博士研究生Supported by:
摘要：
局部麻醉药，简称局麻药，临床上广泛用于皮肤黏膜麻醉、周围神经阻滞及脊髓神经麻醉等。但这类药物对多种组织器官，尤其是神经系统和心血管系统，具有时间及剂量依赖性的毒性作用，并且不同局麻药的毒性表现也有所差异。目前对局麻药的神经毒性研究日益增多，该文对局麻药的神经系统毒性及相关防治方法进行
综述。
中图分类号:
刑媛，张楠,张炜，任雷鸣.局麻药的中枢神经系统毒性与防治[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2018.03.003.
XING Yuan，ZHANG Nan，ZHANG Wei，REN Lei-ming.Neurotoxicity and Prevention of Local Anesthetics in Central Nervous System[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2018.03.003.
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