<strong>慢性脑低灌注致血管性痴呆的病理机制和模型建立</strong>

慢性脑低灌注致血管性痴呆的病理机制和模型建立

1. 中国中医科学院西苑医院老年病科，北京，100091，中国#br# 2. 中国中医科学院西苑医院心血管病科，北京，100091，中国#br# 3. 北京市中医管理局，北京，100053，中国

1. 中国中医科学院西苑医院老年病科，北京，100091，中国
2. 中国中医科学院西苑医院心血管病科，北京，100091，中国
3. 北京市中医管理局，北京，100053，中国

出版日期:2019-02-26发布日期:2020-01-09
通讯作者:刘剑刚，研究员，研究生导师；研究方向：心血管药理学，心血管病及老年病的中西医结合基础和临床研究
作者简介:孙成成，女，博士研究生；研究方向：中西医结合防治老年病的临床和基础研究；E-mail:925019777@qq.com
基金资助:
北京市科技计划项目“十病十药”研发课题资助(No.Z171100001717016)

Exploration of Pathological Mechanism of Vascular Dementia Induced by Chronic Cerebral Hypoperfusion and Production of Several Common Animal Models

1. Department of Geriatrics，Xiyuan Hospital，China Academy of Traditional Chinese Medicine，Beijing，100091，China#br# 2. Department of Cardiology，Xiyuan Hospital，China Academy of Traditional Chinese Medicine，Beijing，100091，China#br# 3. Beijing Municipal Administration of Traditional Chinese Medicine，Beijing，100053，China

1. Department of Geriatrics，Xiyuan Hospital，China Academy of Traditional Chinese Medicine，Beijing，100091，China
2. Department of Cardiology，Xiyuan Hospital，China Academy of Traditional Chinese Medicine，Beijing，100091，China
3. Beijing Municipal Administration of Traditional Chinese Medicine，Beijing，100053，China

Online:2019-02-26Published:2020-01-09
Contact:刘剑刚，研究员，研究生导师；研究方向：心血管药理学，心血管病及老年病的中西医结合基础和临床研究
About author:孙成成，女，博士研究生；研究方向：中西医结合防治老年病的临床和基础研究；E-mail:925019777@qq.com
Supported by:
北京市科技计划项目“十病十药”研发课题资助(No.Z171100001717016)

摘要/Abstract

摘要：

血管性痴呆（vascular dementia，VaD）是由脑血管疾病导致脑功能损害的一类疾病，主要表现为认知能力、学习记忆的下降。血管因素是影响其发病的主要因素，慢性脑低灌注是导致血管功能障碍致机体认知功能受损重要的危险因素，适合的动物模型是研究其病理机制的重要手段。该文概述了脑低灌注致脑血管疾病在认知功能障碍和痴呆发展过程中的病理机制及几种常用的实验性慢性脑低灌注动物模型的制作，探讨其和血管痴呆病理机制的相关性，以期为药物干预慢性脑低灌注致血管性痴呆提供适合的动物模型并为临床药物的机制研究提供借鉴。

Abstract:

Vascular dementia （VaD） is a type of cerebrovascular diseases that can cause brain damages，which is mainly characterized by cognitive capacity，learning and memory decline. As vascular factors are the main factors affecting their onset. Chronic cerebral hypoperfusion is an important risk factor for cognitive dysfunction of the body caused by vascular dysfunction，so the suitable animal model is an important mean to study its pathological mechanism. This article outlines the pathological mechanism of cerebral vascular disease caused by cerebral hypoperfusion in the development of cognitive dysfunction and dementia and the production of several commonly used experimental chronic cerebral hypoperfusion animal models，and explore the correlation with the pathological mechanism of cerebral vascular diseases，in order to provide suitable animal models for the study of drug-interventional chronic cerebral hypoperfusion-induced vascular dementia and references for the mechanisms researchs of clinical drugs.

Key words:chronic cerebral hypoperfusion,cerebral ischemia,vascular dementia,cerebral small vessel disease,pathological factors,animal models

中图分类号:

R332

孙成成，刘剑刚，刘美霞，李浩，罗增刚.慢性脑低灌注致血管性痴呆的病理机制和模型建立[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2019.01.003.

SUN Cheng-cheng，LIU Jian-gang，LIU Mei-xia，LI Hao，LUO Zeng-gang.Exploration of Pathological Mechanism of Vascular Dementia Induced by Chronic Cerebral Hypoperfusion and Production of Several Common Animal Models[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2019.01.003.

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慢性脑低灌注致血管性痴呆的病理机制和模型建立

Exploration of Pathological Mechanism of Vascular Dementia Induced by Chronic Cerebral Hypoperfusion and Production of Several Common Animal Models

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