药物治疗溃疡性结肠炎的信号通路研究进展

神经药理学报››2020,Vol. 10››Issue (4): 41-50.DOI:10.3969/j.issn.2095-1396.2020.04.008

药物治疗溃疡性结肠炎的信号通路研究进展

郭子霞，安子璇，张健美，张丹参

1 欧宝平台登录药学系，张家口，075000，中国
2 河北科技大学，石家庄，050018，中国

出版日期:2020-08-26发布日期:2020-08-26
通讯作者:张丹参，教授，博士，博士生导师；研究方向：神经药理学；E-mail：zhangds2011@126.com
作者简介:郭子霞，硕士研究生；研究方向：药理学；E-mail：2389707795@qq.com
基金资助:

河北省重点研发计划项目生物医药专项（No.20372509D）；河北省自然科学基金（No.H2020208032）；河北省高等学校科学技

术研究项目（No.ZD2020117）；河北省中医药管理局中医药科研计划项目（No.2020268）；中央财政公共卫生专项“中药资源普

查项目”（No.Z135080000022）

Research Progress of Signal Pathways in Drug Treatment of Ulcerative Colitis

GUO Zi-xia，AN Zi-xuan，ZHANG Jian-mei，ZHANG Dan-shen

1. Department of Pharmacy，Hebei North University，Zhangjiakou，075000，China
2. Hebei University of Science and Technology，Shijiazhuang，050018，China

Online:2020-08-26Published:2020-08-26
Contact:张丹参，教授，博士，博士生导师；研究方向：神经药理学；E-mail：zhangds2011@126.com
About author:郭子霞，硕士研究生；研究方向：药理学；E-mail：2389707795@qq.com
Supported by:
河北省重点研发计划项目生物医药专项（No.20372509D）；河北省自然科学基金（No.H2020208032）；河北省高等学校科学技
术研究项目（No.ZD2020117）；河北省中医药管理局中医药科研计划项目（No.2020268）；中央财政公共卫生专项“中药资源普
查项目”（No.Z135080000022）

摘要/Abstract

摘要：

溃疡性结肠炎（ulcerative colitis，UC）是一种受多因素共同影响的疾病，易反复发作，是世界公认的难治病之一，目前药物治疗效果不佳，所以越来越引起人们重视。该文主要综述UC 及治疗药物作用的相关信号通路，为以后新药或新机制研究提供更多参考依据，并对实验所用动物模型的造模方法进行分类评价，以期为研究者选择合适的模型提供参考。

关键词:溃疡性结肠炎,造模方法,药物治疗,信号通路

Abstract:

Ulcerative colitis （UC） is a disease affected by multiple factors and is prone to repeated attacks. It is one of the most intractable diseases recognized in the world. The effect of current drug treatment is not good，so people pay more and more attention to it. This article mainly reviews the signal pathways related to UC pathogenesis and the effects of therapeutic drugs，to provide more reference for future research on new drugs or new mechanisms，and to classify and evaluate the modeling methods of animal models used in experiments，in order to provide references for researchers to choose suitable models.

Key words:ulcerative colitis,modeling method,medication,signal pathway

中图分类号:

R574.62

郭子霞, 安子璇, 张健美, 张丹参. 药物治疗溃疡性结肠炎的信号通路研究进展[J]. 神经药理学报, 2020, 10(4): 41-50.

GUO Zi-xia, AN Zi-xuan, ZHANG Jian-mei, ZHANG Dan-shen. Research Progress of Signal Pathways in Drug Treatment of Ulcerative Colitis[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(4): 41-50.

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