神经药理学报››2020,Vol. 10››Issue (6): 45-47.DOI:10.3969/j.issn.2095-1396.2020.06.008

• 综述 •上一篇下一篇

VASH-2 与肿瘤关系的研究进展

徐凯伦,张志华,高艳松

  1. 1. 欧宝平台登录 研究生学院,张家口,075000,中国
    2. 欧宝平台登录 附属第一医院呼吸内科,张家口,075000,中国
  • 出版日期:2020-12-26发布日期:2020-12-26
  • 通讯作者:张志华,男,主任医师,教授,硕士研究生导师;研究方向:呼吸系统疾病相关研究
  • 作者简介:徐凯伦,男,欧宝平台登录 2018 级研究生 ; 研究方向:呼吸系统疾病相关研究
  • 基金资助:
    2020 年河北省省级科技计划(No.20377717D)

Research Progress On The Relationship Between VASH-2 And Tumor

XU Kai-lun,ZHANG Zhi-hua,GAO Yan-song

  1. 1. Graduate School of Hebei North University,Zhangjiakou,075000, China
    2. Department of Respiratory Medicine,the First Affiliated Hospital of Hebei North University,Zhangjiakou, 075000, China
  • Online:2020-12-26Published:2020-12-26
  • Contact:张志华,男,主任医师,教授,硕士研究生导师;研究方向:呼吸系统疾病相关研究
  • About author:徐凯伦,男,欧宝平台登录 2018 级研究生 ; 研究方向:呼吸系统疾病相关研究
  • Supported by:
    2020 年河北省省级科技计划(No.20377717D)

摘要:

血管生成参与肿瘤的发生、侵袭和转移,在肿瘤发展过程中起到重要作用。Vasohibin家族是最近发现 的影响血管生成的调节因子,VASH-1VASH-2是该家族的重要成员,参与肿瘤生成和发展。VASH-1在肿瘤 发病过程中起到负性调控作用,VASH-2则促进血管生成。该文对VASH-2与肿瘤关系进行综述,探讨VASH-2在肿瘤中的作用,为血管靶向抗癌药物的研发提供新思路。

关键词:vasohibin 家族,VASH-2,血管生成

Abstract:

Angiogenesis is involved in the occurrence, invasion and metastasis of tumors, and plays an important role in the development of tumors. The Vasohibin family is a recently discovered regulatory factor that affects angiogenesis. VASH-1 and VASH-2 are important members of this family and are involved in tumor generation and development. VASH-1 plays a negative regulatory role in tumor pathogenesis, and VASH-2 promotes angiogenesis. This paper reviews the relationship between VASH-2 and tumors, discusses the role of VASH-2 in tumors, and provides new ideas for the development of blood vessel-targeted anti-cancer drugs.

Key words:vasohibin family,VASH-2,angiogenesis

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