神经药理学报

神经药理学报››2021,Vol. 11››Issue (4): 38-.DOI:10.3969/j.issn.2095-1396.2021.04.008

• 综述 •上一篇下一篇

姜黄素抗脑缺血再灌注损伤的药理学研究进展

孙玉，李鹏，杨鹏飞

  1. 新乡医学院药学院，河南省心血管重构与药物干预国际联合实验室，新乡市心血管重构干预与分子靶向治疗重点实验室，新乡，453003，中国

  • 出版日期:2021-08-26发布日期:2021-08-26
  • 通讯作者:杨鹏飞，男，硕士生导师；研究方向：神经药理学；Tel/Fax：0373-3029101，E-mail：171048@xxmu.edu.cn
  • 作者简介:孙玉，女，硕士研究生；研究方向：临床药学与应用；E-mail：2316903766@qq.com
  • 基金资助:

    河南省自然科学基金面上项目（No.212300410383），河南省自然科学基金项目（No.202300410308、No.2018GGJS102、No.18HASTIT047、No.ZD2020006、No.212102311046），新乡医学院基金（No.XYBSKYZZ201810、No.XYBSKYZZ201626、No.XYBSKYZZ505319、No.YJSCX202041Y、No.KYCX2020-38），国家自然科学基金（No.81874312、No.U1804197）

Advances in Pharmacological Researches of Curcumin on Brain Ischemia-Reperfusion Injury

SUN Yu，LI Peng，YANG Peng-fei

  1. College of Pharmacy，Xinxiang Medical University；Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention；Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development，Xinxiang，453003，China

  • Online:2021-08-26Published:2021-08-26

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摘要：

脑卒中指由于急性的血液循环障碍导致神经功能出现明显的缺损症状，是全球成年人永久性致残的首要元凶。其病理损伤过程包括由缺血引起的原发性脑损伤、再灌注后引发的缺血再灌注损伤，其中脑缺血再灌注损伤是造成患者致死致残的更为重要的原因。姜黄来源于姜科姜黄属植物姜黄的干燥根茎，姜黄素为其主要的生物学成分，具有广泛的药理学活性，该文从脑缺血再灌注损伤时的病理发生机制：线粒体功能障碍、氧化应激、炎症作用、兴奋性氨基酸毒性、钙超载及细胞程序性死亡方面，对姜黄素在缓解脑缺血再灌注损伤方面的药理学作用进行探讨，以期为姜黄素的研究和开发提供基础性理论支持。

关键词:姜黄,姜黄素,脑缺血再灌注损伤,药理学作用

Abstract:

Stroke is the primary cause for permanent disability in adults worldwide，and characterized by the obvious neurological deficit symptoms resulted from acute blood circulation disorder. Two pathological damage processes involved in stroke，including primary brain injury caused by ischemia and ischemia-reperfusion injury caused by rapid blood flow recovery，and the latter one plays more important role in causing death and disability in stroke patients. Curcumin，which is the main active component in the dried rhizome of Curcuma longa L.，possesses a wide range of pharmacological activities. This review based on the pathological mechanism of cerebral ischemia-reperfusion injury，including mitochondrial dysfunction，oxidative stress，neuroinflammation，excitatory amino acid toxicity，calcium overload and programmed death of neurons，discussed the pharmacological benefit of curcumin in alleviating cerebral ischemiareperfusion injury，and hopes to provide theoretical basis for the mechanism study and the development of curcumin.

Key words:turmeric,brain ischemia/reperfusion injury,pharmaceutical benefit

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