糖皮质激素与海马结构可塑性

摘要/Abstract

摘要：神经元突触、星形胶质细胞和神经营养因子共同构成了海马的结构可塑性。长期高水平糖皮质激素可损伤海马的结构可塑性，并能被抗糖皮质激素治疗所逆转，说明糖皮质激素是慢性应激致海马结构可塑性损伤的重要病理环节。据此，在学习记忆障碍和抑郁动物模型的复制中，糖皮质激素注射被用来取代应激刺激以提高效率和模型复制的稳定性。此外，短期高水平糖皮质激素可增强海马的结构可塑性，暗示糖皮质激素对海马结构可塑性的调节是双向的。

关键词:糖皮质激素,皮质酮,海马,结构可塑性,动物模型

Abstract:Chronic high dose glucocorticoid exposure produces the major disruption to the hippocampal structural plasticity（such as plastic changes in spine and dendrite morphology, astrocyte as well as adult neurogenesis）, which can be reversed by anti-glucocorticoid therapy,indicating that glucocorticoids play a crucial role in chronic stress-induced impairment of hippocampal structural plasticity. Thus, one way to avoid the variable effects of stress exposure on animal behavior is developed by using exogenous corticosterone administration as a means to enhance efficiency and stability of animal model. Interestingly, short-term or acute glucocorticoid exposure has the ability to enhance structural plasticity, suggesting that the regulation of glucocorticoids on hippocampal structural plasticity is bidirectional.

Key words:glucocorticoids,corticosterone,hippocampus,structural plasticity,animal model

中图分类号:

R363

陈琳，杜力军，赵玉男. 糖皮质激素与海马结构可塑性[J]. 神经药理学报, 2011, 1(2): 58-64.

CHEN Lin，DU Li-jun，ZHAO Yu-nan. Glucocorticoids and Hippocampal Structural Plasticity[J]. Acta Neuropharmacologica, 2011, 1(2): 58-64.

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