神经药理学报››2011,Vol. 1››Issue (4): 55-64.

• 综述 •上一篇

人参防治帕金森病的研究进展

李东薇,窦德强

  1. 辽宁中医药大学药学院,大连,116600,中国
  • 出版日期:2011-08-26发布日期:2012-11-24
  • 通讯作者:窦德强,男,教授,博士研究生导师;Tel:+86-0411-87406497,E-mail:doudeqiang2003@yahoo.com.cn
  • 作者简介:李东薇,女,硕士研究生在读;研究方向:中药药效物质基础;E-mail:wei-5599@163.com

Research Advances in Using Ginseng to Prevent and Treat Parkinson’s Disease

LI Dong-wei,DOU De-qiang

  1. Liaoning University of Traditional Chinese Medicine,Dalian,116600,China
  • Online:2011-08-26Published:2012-11-24

摘要:归纳总结了帕金森病(Parkinson’s disease,PD)的研究概况、人参防治帕金森病的药理作用及其有效成分人参皂苷在保护黑质多巴胺能神经元方面相关作用机制的研究进展,为人参在防治帕金森病方面的合理应用奠定了基础。人参皂苷可能通过拮抗氧化应激反应、抑制钙通道和阻断引起神经元凋亡的多条信号通路等机制,保护多巴胺能神经元。

关键词:帕金森病,人参,人参皂苷,多巴胺,神经保护作用

Abstract:The current research in Parkinson’s disease and progress in using of ginseng to treat Parkinson’s disease,and mechanisms of ginsenosides-induced protection of dopaminergic neurons in substantia nigra were reviewed,which lay a foundation for the reasonable application of ginseng in the treatment of Parkinson’s disease. Ginsenosides can play an important role in protecting dopaminergic neurons by countering oxidative stress,inhibiting Ca2+channel and blocking the signaling pathways of neurons apoptosis.

Key words:PD,ginseng,ginsenoside,dopamine(DA),neuroprotective effects

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