神经药理学报››2012,Vol. 2››Issue (1): 1-9.
• 研究论文 •下一篇
ZHAI Yun-peng, ZHU Xia, LU Qian, WANG Jian-yun, YIN Xiao-xing, LIU Yao-wu
出版日期:
2012-02-26发布日期:
2013-05-06作者简介:
ZHAI Yun-peng, female, Lecturer, M.P.; Research Direction: diabetic encephalopathy.基金资助:
ZHAI Yun-peng, ZHU Xia, LU Qian, WANG Jian-yun, YIN Xiao-xing, LIU Yao-wu
Online:
2012-02-26Published:
2013-05-06About author:
ZHAI Yun-peng, female, Lecturer, M.P.; Research Direction: diabetic encephalopathy.Supported by:
the Exclusive Funds of Talent in Xuzhou Medical College (No.2010KJZ06), andthe Natural Science Foundation of Jiangsu Province (No.BK2011208).
摘要:目的:观察知母总皂苷(saponins fromRhizoma Anemarrhenae, TS)对糖尿病(diabetes mellitus, DM)大鼠海马中乙酰胆碱酯酶(acetylcholinesterase, AchE)活性的影响及可能机制。方法:雄性Sprague Dawley大鼠单次腹腔注射链脲霉素(streptozotocin, STZ, 55 mg?kg-1)诱导DM大鼠模型后,按血糖值随机分为DM组和TS组,TS组灌胃给予TS(200 mg?kg-1),每天一次,连续8周。测定海马中AchE活性、丙二醛(malondialdehyde, MDA)和还原型谷胱甘肽(reduced glutathione, GSH)水平,以及血清中MDA、GSH和葡萄糖水平。结果:相对于正常大鼠,8周病程的DM大鼠海马中AchE活性显著增加,给予TS能够改善上述变化。同时,DM大鼠海马和血清中MDA水平显著增加、GSH明显降低,而TS干预后能够明显逆转。此外,TS还能够明显降低DM大鼠的空腹血糖和增加体重。结论:知母总皂苷对糖尿病状态下海马中AchE活性具有一定的改善作用,这可能与其抗氧化应激和改善DM基本症状有关。
中图分类号:
ZHAI Yun-peng, ZHU Xia, LU Qian, WANG Jian-yun, YIN Xiao-xing, LIU Yao-wu.Total Saponins fromRhizoma AnemarrhenaeIncrease Acetylcholinesterase Activity in the Hippocampus of Diabetic Rats /知母总皂苷改善糖尿病大鼠海马中乙酰胆碱酯酶的活性[J]. 神经药理学报, 2012, 2(1): 1-9.
ZHAI Yun-peng, ZHU Xia, LU Qian, WANG Jian-yun, YIN Xiao-xing, LIU Yao-wu.Total Saponins fromRhizoma AnemarrhenaeIncrease Acetylcholinesterase Activity in the Hippocampus of Diabetic Rats[J]. Acta Neuropharmacologica, 2012, 2(1): 1-9.
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