神经药理学报››2012,Vol. 2››Issue (2): 42-47.
张玮1,2,韩宁1,胡金凤1,陈乃宏1
出版日期:
2012-04-26发布日期:
2013-11-01通讯作者:
陈乃宏,男,博士,研究员;研究方向:神经药理;Tel:+86-010-63165177, E-mail: chennh@imm.ac.cn作者简介:
张玮,女,硕士研究生;研究方向:脑血管药理;E-mail: luxixi1987@126.com基金资助:
国家国际科技合作项目(No.2010DFB32900),国家自然科学基金(No.81173578、No.81274122),国家“重大新药创制”科技重大专项(No.2012ZX09103101-006、No.2012ZX09301002-004),教育部创新团队(No.IRT1007),北京市自然基金(No.7131013)
ZHANG Wei1,2, HAN Ning1, HU Jinfeng1, CHEN Nai-hong1
Online:
2012-04-26Published:
2013-11-01Contact:
陈乃宏,男,博士,研究员;研究方向:神经药理;Tel:+86-010-63165177, E-mail: chennh@imm.ac.cnAbout author:
张玮,女,硕士研究生;研究方向:脑血管药理;E-mail: luxixi1987@126.comSupported by:
国家国际科技合作项目(No.2010DFB32900),国家自然科学基金(No.81173578、No.81274122),国家“重大新药创制”科技重大专项(No.2012ZX09103101-006、No.2012ZX09301002-004),教育部创新团队(No.IRT1007),北京市自然基金(No.7131013)
摘要:对近年来有关蛇床子素脑缺血保护作用研究的文章进行总结,我们发现其不仅能抑制脑缺血再灌过程中的炎性反应、减轻脑水肿而保护受损脑组织,还能增加缺血脑组织中抗氧化酶的活性,清除氧自由基而减少再灌过程中自由基带来的损伤。此外蛇床子素还展现了良好的抗凝抗血栓作用,因此我们从抗炎、抗氧化、抗凝、抗凋亡等几个方面分析蛇床子素发挥保护作用的可能作用机制,以期为进一步研究蛇床子素防治脑缺血的药理作用提供参考。
中图分类号:
张玮,韩宁,胡金凤,陈乃宏.蛇床子素对脑缺血损伤的保护作用机制研究进展[J]. 神经药理学报, 2012, 2(2): 42-47.
ZHANG Wei, HAN Ning, HU Jinfeng, CHEN Nai-hong.Reseach Progress in the Mechanism of Osthole in Protecting Brain Ischemia[J]. Acta Neuropharmacologica, 2012, 2(2): 42-47.
[1] Veronique L Roger, Alan S Go, Donald M Lloyd-Jones, et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association [J]. Circulation, 2011, 123(4): e18–e209. [2] Zhang Qiao-yan, Qin Lu-ping, He Wei-dong, et al. Coumarins from Cnidium monnieri and their antiosteoporotic activity [J]. Planta Med, 2007, 73(1): 13–19. [3] Chiu Pu-Rong, Lee Wei-Te, Chu Yu-Te, et al. Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells [J]. Pediatr Neonatol, 2008, 49(4): 135–140. [4] Liang Hong-Jen, Suk Fat-Moon, Wang Chung-Kwe, et al. Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice [J]. Chem Biol Interact, 2009, 181(3): 309–315. [5] Sun Fan, Xie Mei-Lin, Xue Jie, et al. Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine [J]. Phytomedicine, 2010, 17(8-9): 669–673. [6] Chou Szu-Yuan, Hsu Chun-Sen, Wang Kun-Teng, et al. Antitumor effects of osthol from Cnidium monnieri: an in vitro and in vivo study [J]. Phytother Res, 2007, 21(3): 226–230. [7] Jarogneiw J Luszczki, Marta Andres-Mach, Wojciech Cisowski, et al. Osthole suppresses seizures in the mouse maximal electroshock seizure model [J]. Eur J Pharmacol, 2009, 607(1-3): 107–109. [8] Wang Gao-xue, Zhou Zhuang, Cheng Chao, et al. Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermediu in Carassius auratus [J]. Vet Parasitol, 2008, 158(1-2): 144–151. [9] Mao Xue-xuan, Yin Wei, Liu Meng, et al. Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats [J]. Brain Res, 2011, 1385: 275-280. [10] Li Fei, Gong Qin-hai, Wang Lina. Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats [J]. Biol Pharm Bull, 2012, 35 (10):1686-1690. [11] He Ya-long, Qu Shuo-yao, Wang Jiang, et al. Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats [J]. Brain Res, 2012, 1433: 127-136. [12] Michael A Moskowitz, Eng H Lo, Costantino Iadecola. The science of stroke: mechanisms in search of treatments [J]. Neuron, 2010, 67(2): 181–198. [13] Donna L Carden, D Neil Granger. Pathophysiology of ischaemia-reperfusion injury [J]. J Pathol, 2000, 190(3): 255–266. [14] Ellinor I Peerschke, Wei Yin, Berhane Ghebrehiwet. Complement activation on platelets: implications for vascular inflammation and thrombosis [J]. Mol Immunol, 2010, 47(13): 2170–2175. [15] Holger K Eltzschig, Peter Carmeliet. Hypoxia and inflammation [J]. N Engl J Med, 2011, 364(7): 656–665. [16] 王宇卉, 邵福源.炎性细胞因子在缺血性脑损伤中的作用[J].临床神经病学杂志, 2000, 4(13): 249-250. [17] 黄承乐, 马付坚.炎性细胞因子缺血性脑损伤中的作用[J].右江民族医学院学院报, 2003, 5(25): 678-679. [18] Karikó Katalin, Drew Weissman, Frank A Welsh. Inhibition of toll-like receptor and cytokine signaling-a unifying theme in ischemic tolerance [J]. J Cereb Blood Flow Metab, 2004, 24(11): 1288-1304. [19] 刘一鸥, 金便芬, 张林静, 等.脑梗死患者血浆脂联素和肿瘤坏死因子-α与病情轻重的关系[J].中国全科医学, 2007, 10(20):1681. [20] Coleone A C, Torres K A, Carnio E C, et al. Role of brain nitric oxide in the thermoregulation of broiler chicks [J]. Comp Biochem Physiol A Mol Integr Physiol, 2009, 154(2): 204–210. [21] 韩英, 刘楠, 陈荣华, 等.IL-8在大鼠脑缺血再灌注损伤中变化的实验研究[J].中国动脉硬化杂志, 2005, 12(3):112. [22] 吴建华, 方云祥.法舒地尔对大鼠脑缺血再灌注损伤炎症反应的影响[J].中国临床药理学与治疗学, 2008, 13(4):377. [23] Chao Xiao-dong, Zhou Jun, Chen Tao, et al. Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats [J]. Brain Res, 2010, 1363: 206-211. [24] 何蔚, 刘建新, 周钰梅, 等. 蛇床子素对大鼠脑缺血/再灌注损伤的保护作用极其机制[J]. 中国药理学通报, 2008, 24(11): 1528-1530. [25] 谭毓治, 蔡飒, 李校堃, 等. 非促分裂型haFGF 对小鼠脑缺血/再灌注损伤的保护作用[J] . 中国药理学通报, 2007, 23(6) : 738- 41. [26] 于鹏霞, 喻婉莹, 阚伟娟, 等. 蛇床子素的抗炎作用极其机制[J]. 时珍国医国药, 2012, 23(4): 866-68. [27] Sugawara Taku, Pak H Chan. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia [J]. Antioxid. Redox Signal, 2003, 5(5): 597–607. [28] Slemmer J E, Shacka J J, Sweeney M I, et al. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging [J]. Curr Med Chem, 2008, 15(4):404-414. [29] Hai Chen, Hideyuki Yoshioka, Gab Seok Kim, et al. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection [J]. Antioxidants Redox Signaling, 2011, 8(14): 1505-1517. [30] Ji Hai-Jie, Hu Jin-Feng, Wang Yong-Hui, et al. Osthole improves chrnic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus [J]. Eur J Pharmacol, 2010, 636(1-3): 96-101. [31] 沈丽霞, 张丹参, 张力, 等.蛇床子素对学习记忆的影响及其机制分析[J]. 药学学报, 1999, 34(6): 405-409. [32] 沈丽霞, 金乐群, 张丹参, 等. 蛇床子素对AlCl3 致急性衰老模型小鼠记忆障碍的保护作用[ J] . 药学学报, 2002, 37( 3) :178-180. [33] 王书华, 安芳, 张丹参. 蛇床子素抗氧自由基清除作用的研究[J]. 中成药, 2004, 26(12):1062-1063. [34] Ko F N, Wu T S, Liou M J, et al. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens [J]. Thromb Haemost, 1989, 62(3): 996-999. [35] 周俐,刘建新,周青,等. 蛇床子素抗凝血作用[J]. 中国药理与临床, 2006, 22(3-4): 42-43. [36] Robble YK, Chen Wen-Fang, Aling Dong, et al. Estrogen-Like activity of ginsenoside Rg1 derived from Panax notoginseng [J]. J Clin Endocrinol Metab, 2002, 87(8): 3691-3695. [37] 陈蓉, 陈梅林. 蛇床子素抑制血栓形成极其作用机制研究[J]. 中国现代医药杂志, 2008, 10(10): 50-52. [38] 陈蓉, 谢梅林, 周佳. 蛇床子素抑制血栓形成和血小板聚集的实验研究[J]. 中国药理学通报, 2005, 21(4): 440-443. [39] 刘文博, 霍军丽, 费舟, 等. 蛇床子素在缺血再灌注脑损伤模型中的脑保护作用[J]. 中华神经外科疾病研究杂志, 2009, 8(2): 118-121. [40] Rosell Anna, Lo Eng H. Multiphasic roles for matrix metalloproteinases after stroke [J]. Curr Opin Pharmacol, 2008, 8(1): 82–89. [41] Rosell Anna, Ortega-Aznar Arantxa, Alvarez-Sabin Jose, et al. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke [J]. Stroke, 2006, 37(6): 1399–1406. [42] Zhao Bing-Qiao, Tejima Emiri, Lo Eng H. Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke [J]. Stroke, 2007, 38(2 Suppl): 748–752. [43] Lee Seong-Ryong, Kim Hahn-Young, Hong Jung Suk, et al. PPAR gamma agonist pioglitazone reduces matrix metalloproteinase-9 activity and neuronal damage after focal cerebral ischemia [J]. Biochem Biophys Res Commun, 2009, 380(1): 17–21. [44] Tanaka Hidekazu, Takai Shinji, Jin Denan, et al. Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats [J]. Hypertens Res, 2007, 30(5): 469–475. [45] Hsieh Ming-Tsuen, Hsieh Chia-Ling, Wang Wen-Hsin, et al. Osthole improves aspects of spatial performance in ovariectomized rats [J]. Am J Chin Med, 2004, 32(1):11-20. [46] 何蔚, 连其深, 刘建新. 蛇床子素对大鼠局灶性脑缺血再灌注损伤的保护作用[J]. 中草药, 2009, 40 (1) : 86-89. |
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