神经药理学报››2013,Vol. 3››Issue (1): 37-47.

• 综述 •上一篇下一篇

睡眠影响记忆巩固的研究进展

盛兆福,张永鹤

  1. 北京大学基础医学院药理系,北京,100191,中国
  • 出版日期:2013-02-26发布日期:2014-06-27
  • 通讯作者:张永鹤,男,教授,博士生导师;研究方向:睡眠及精神神经药理;E-mail: zhyh@hsc.pku.edu.cn
  • 作者简介:盛兆福,男,博士研究生;研究方向:睡眠及精神神经药理;E-mail:jianbingxuan@163.com
  • 基金资助:

    国家自然科学基金项目(No:81173031)

Effect of Sleep on Memory Consolidation

SHENG Zhao-fu, ZHANG Yong-he

  1. Department of Pharmacology, School of Basic Medical Science, Peking University, Bejing, 100191, China
  • Online:2013-02-26Published:2014-06-27
  • Contact:张永鹤,男,教授,博士生导师;研究方向:睡眠及精神神经药理;E-mail: zhyh@hsc.pku.edu.cn
  • About author:盛兆福,男,博士研究生;研究方向:睡眠及精神神经药理;E-mail:jianbingxuan@163.com
  • Supported by:

    国家自然科学基金项目(No:81173031)

摘要:学习后睡眠有利于记忆巩固。学习的类型不同,睡眠依赖的记忆巩固机制可能也有所不同,涉及到不同脑区在不同的睡眠时相的生理功能。睡眠有助于长时程增强(long-term potentiation,LTP)的形成,进而促进记忆的巩固。总睡眠剥夺、快动眼睡眠剥夺、片段性睡眠可以通过不同的分子生物学机制损伤记忆巩固。

关键词:睡眠,学习,记忆,脑电图,长时程增强

Abstract:Delayed post learning sleep but not wakefulness enhances memory consolidation. Different types of learning have unique sleep-related memory consolidation mechanisms that act in dissociable brain regions during different sleep phases throughout the night. Sleep exerts beneficial effect on memory consolidation by improving formation of long-term potentiation. Total sleep deprivation, rapid eye movement sleep deprivation and sleep fragmentation may lead to memory deficits through different molecular mechanisms.

Key words:sleep,learning,memory,electroencephalography,long-term potentiation

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