神经药理学报››2013,Vol. 3››Issue (3): 19-26.
王琪,段冷昕
出版日期:
2013-06-26发布日期:
2014-06-27通讯作者:
段冷昕,博士,硕士生导师;研究方向:神经药理学方面基础研究;Email:lengxinduan@163.com作者简介:
王琪,女,在读硕士生;Email:765006812@qq.com基金资助:
国家自然科学基金项目(No.U1204826),河南省卫生厅科技攻关项目(No.200903110)
WANG Qi,DUAN Leng-xin
Online:
2013-06-26Published:
2014-06-27Contact:
段冷昕,博士,硕士生导师;研究方向:神经药理学方面基础研究;Email:lengxinduan@163.comAbout author:
王琪,女,在读硕士生;Email:765006812@qq.comSupported by:
国家自然科学基金项目(No.U1204826),河南省卫生厅科技攻关项目(No.200903110)
摘要:内质网是真核细胞中重要的细胞器之一,与维持细胞稳态关系密切。当缺乏葡萄糖、缺氧、体内钙平衡紊乱或者发生氧化应激时,会引起细胞内未折叠蛋白或错误折叠蛋白的积累,导致内质网应激。帕金森病是一种慢性进行性脑变性疾病,典型的病理变化是黑质纹状体多巴胺能神经细胞变性丢失导致的多巴胺神经递质缺乏。目前对帕金森病的治疗多为缓解症状,但不能阻止疾病的进展。通过对内质网应激中的信号通路的研究发现:在帕金森病的发病过程中,多巴胺能神经元的选择性死亡与内质网应激有关。内质网应激过程中的中心调节因子:葡萄糖调节蛋白78(GRP78)及其下游ATF4–CHOP–Puma信号通路与帕金森病的发病过程有密切的联系,本文对GRP78及其下游ATF4–CHOP–Puma信号通路近些年来的研究进展进行综述,以期为帕金森病的治疗提供新的靶点和思路。
中图分类号:
王琪, 段冷昕.内质网应激中GRP78和ATF4–CHOP–Puma信号通路与帕金森病的关系及其治疗靶点的研究进展[J]. 神经药理学报, 2013, 3(3): 19-26.
WANG Qi, DUAN Leng-xin.Progress on the Involvement of GRP78 and ATF4 – CHOP – Puma Signaling Pathway in Endoplasmic Reticulum Stress and Parkinson's Disease[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(3): 19-26.
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