神经药理学报››2013,Vol. 3››Issue (6): 25-32.
何娜，殷明，王泽剑
出版日期:2013-12-26发布日期:2014-06-27通讯作者:王泽剑，男，博士，副教授，硕士生导师；研究方向：神经药理；E-mail: wangzejian@sjtu.edu.cn作者简介:何娜，女，药理学博士研究生；研究方向：神经药理；E-mail: hena0726happy@163.com基金资助:
国家自然科学基金项目（No.81270432）
HE Na, YIN Ming, WANG Ze-jian
Online:2013-12-26Published:2014-06-27Contact:王泽剑，男，博士，副教授，硕士生导师；研究方向：神经药理；E-mail: wangzejian@sjtu.edu.cnAbout author:何娜，女，药理学博士研究生；研究方向：神经药理；E-mail: hena0726happy@163.comSupported by:
国家自然科学基金项目（No.81270432）
摘要：海马神经再生持续于哺乳动物整个成年期。在生理刺激以及脑外伤等病理因素的刺激下，神经干细胞可发生增殖、迁移、分化，最终整合到神经元网络中。阿尔茨海默病（Alzheimer,s disease，AD）是一种中枢神经系统退行性疾病，主要病理学特征为细胞内外β淀粉样蛋白（β-amyloid peptide, Aβ）沉积、细胞内神经原纤维缠结（neurofibrillary tangles, NFT），以及由这些引发的神经元变性、坏死。目前，应用海马神经再生治疗AD已成为极具潜力的治疗手段。该文综述了最近成年海马神经再生与AD关系的研究进展。
中图分类号:
何娜，殷明，王泽剑.成年海马神经再生与阿尔茨海默病关系的研究进展[J]. 神经药理学报, 2013, 3(6): 25-32.
HE Na, YIN Ming, WANG Ze-jian. Progress in the Relationship of Adult Hippocampal Neurogenesis and Alzheime’s Disease[J]. Acta Neuropharmacologica, 2013, 3(6): 25-32.
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