神经药理学报››2014,Vol. 4››Issue (2): 27-38.
王莹, 刘玉刚, 张丹参
出版日期:2014-04-26发布日期:2014-06-27通讯作者:张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail：zhangds2011@126.com作者简介:王莹，女，博士研究生；研究方向：神经药理学,E-mail：990060606@163.comWANG Ying, LIU Yu-gang, ZHANG Dan-shen
Online:2014-04-26Published:2014-06-27Contact:张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail：zhangds2011@126.comAbout author:王莹，女，博士研究生；研究方向：神经药理学；E-mail：990060606@163.com摘要：阿尔茨海默病（Alzheimer's Disease, AD）是一种神经退行性疾病，临床表现为认知功能障碍，病理学研究发现脑萎缩，细胞外老年斑（senile plaque, SP）沉积及细胞内出现神经纤维缠结（neurofibrillary tangle, NFT）。AD发病机制尚不清楚，因此动物模型的建立对探索其发病机制具有重要意义。本文就AD实验动物模型研究进展作一综述，详细描述并评价了目前常见的AD模型及其在药物研发中的应用。
中图分类号:
王莹, 刘玉刚, 张丹参.阿尔茨海默病实验动物模型方法及评价[J]. 神经药理学报, 2014, 4(2): 27-38.
WANG Ying, LIU Yu-gang, ZHANG Dan-shen.Animal Models of Alzheimer's Disease: a Review[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(2): 27-38.
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