神经药理学报››2014,Vol. 4››Issue (4): 28-35.
卢丹丹,赵静,任雷鸣
出版日期:
2014-08-26发布日期:
2015-01-20通讯作者:
任雷鸣,教授,博士生导师;研究方向:心血管药理学;Tel:+86-0311-86266722,E-mail:ren-leiming@263.net作者简介:
卢丹丹,女,硕士研究生;研究方向:心血管药理学;Tel:+86-0311-86266723,E-mail:ldd121@163.com基金资助:
国家重点基础研究发展计划(973计划)资助项目(2012 CB518601)
LU Dan-dan, ZHAO Jing, REN Lei-ming
Online:
2014-08-26Published:
2015-01-20Contact:
任雷鸣,教授,博士生导师;研究方向:心血管药理学;Tel:+86-0311-86266722,E-mail:ren-leiming@263.netAbout author:
卢丹丹,女,硕士研究生;研究方向:心血管药理学;Tel:+86-0311-86266723,E-mail:ldd121@163.comSupported by:
国家重点基础研究发展计划(973计划)资助项目(2012 CB518601)
摘要:血管功能失调是心脑血管病变发病的主要原因。缺氧时血管内皮细胞和平滑肌细胞通过多种方式迅速反应,包括急性反应和基因水平的改变,进而引起血管扩张或收缩。动脉血氧含量降低通过刺激颈动脉体化学感受器并激活交感神经系统,也能即刻诱发血管功能改变。血红素氧化酶和低氧诱导因子则在缺氧对血管壁的长期效应中发挥主要作用。本文还介绍了长期神经刺激促发血管内皮损伤,促进外膜成纤维细胞及中膜平滑肌细胞增殖和迁移,以及脑血管内皮细胞所参与的神经系统疾病。
中图分类号:
卢丹丹,赵静,任雷鸣.缺氧及血管周围神经改变对心脑血管的影响[J]. 神经药理学报, 2014, 4(4): 28-35.
LU Dan-dan, ZHAO Jing, REN Lei-ming.Effects of Hypoxia and Perarterial Nerve Change on Cardiocerebrovascular System[J]. Acta Neuropharmacologica, 2014, 4(4): 28-35.
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