神经药理学报››2015,Vol. 5››Issue (2): 17-23.
张海红
出版日期:
2015-04-26发布日期:
2015-07-06作者简介:
张海红,女,讲师,硕士,从事中药药代动力学研究,email: zhanghaihongzhh@163.com基金资助:
欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 计划项目(2014013);河北省中医药管理局科研计划项目(2013078)
ZHANG Hai-hong
Online:
2015-04-26Published:
2015-07-06About author:
张海红,女,讲师,硕士,从事中药药代动力学研究,email: zhanghaihongzhh@163.comSupported by:
欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 计划项目(2014013);河北省中医药管理局科研计划项目(2013078)
摘要:兴奋性氨基酸(excitatory amino acids, EAA)是存在于中枢神经系统的兴奋性神经递质,主要包括谷氨酸和天门冬氨酸。谷氨酸受体可分为离子型和代谢型两类。N-甲基-D-天冬氨酸(N-Methyl-D-Aspartate, NMDA)受体是离子型受体的一种亚型。NMDA受体可介导Ca2+内流,增强突触可塑性,参与学习记忆及神经系统发育。另一方面,机体兴奋性氨基酸剧增时,通过激动NMDA受体引起大量的Ca2+内流,细胞内Ca2+超载,进一步激活一系列胞内机制而导致细胞死亡。所以NMDA受体历来被认为是一把双刃剑。NMDA受体活性调节的失衡可能是神经退行性疾病、癫痫及缺血性脑损伤等许多中枢神经系统疾病发病的基础。本文重点就NMDA受体与神经退行性疾病的关系进行综述。
张海红.NMDA受体与中枢神经系统退行性疾病[J]. 神经药理学报, 2015, 5(2): 17-23.
ZHANG Hai-hong.NMDA Receptor and Neurodegenerative Diseases in the Central Nervous System[J]. Acta Neuropharmacologica, 2015, 5(2): 17-23.
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