神经药理学报››2015,Vol. 5››Issue (3): 22-27.
高杨,段冷昕
出版日期:
2015-06-26发布日期:
2015-07-06通讯作者:
段冷昕,博士,硕士生导师;研究方向:神经药理;E-mail:lengxinduan@163.com作者简介:
高杨,男,硕士研究生;E-mail:yxgaoyang@163.com基金资助:
国家自然科学基金(NO:U1204826),河南省卫生厅科技攻关项目(NO:200903110)
GAO Yang,DUAN Leng-xin
Online:
2015-06-26Published:
2015-07-06Contact:
段冷昕,博士,硕士生导师;研究方向:神经药理;E-mail:lengxinduan@163.comAbout author:
高杨,男,硕士研究生;E-mail:yxgaoyang@163.comSupported by:
国家自然科学基金(NO:U1204826),河南省卫生厅科技攻关项目(NO:200903110)
摘要:细胞自噬是真核生物通过溶酶体途径来降解自身产生的错误折叠蛋白,清除细胞内受损伤或者衰老细胞器的过程,对维持细胞内的稳态以及细胞的代谢生长非常重要。近年来对于细胞自噬的研究发现其与肿瘤、心血管及神经退行性疾病的发生发展均有着密切的关系,细胞自噬的过度或者不足均能够对细胞产生毒性,进而导致错误蛋白的产生,加快疾病的发展进程。因此对细胞自噬的产生、分子机制及其在疾病中作用的研究对这些疾病的预防和控制显得尤为重要。神经退行性疾病多是以错误折叠蛋白和内含体的异常聚集为标志的疾病。这些聚集在神经元或神经组织的异常蛋白能够导致细胞毒性反应或者氧化应激,最终引起神经元的退化或死亡,影响患者的认知或运动等功能。本文主要对细胞自噬发生的机制以及细胞自噬和帕金森病以及阿尔兹海默病之间的关系做一综述。
中图分类号:
高杨, 段冷昕.细胞自噬在帕金森病和阿尔茨海默病中的研究进展[J]. 神经药理学报, 2015, 5(3): 22-27.
GAO Yang, DUAN Leng-xin.Advances of Autophagy in Parkinson’s Disease and Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 22-27.
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