神经药理学报››2015,Vol. 5››Issue (3): 36-45.
姜懿纳， 陈乃宏
出版日期:2015-06-26发布日期:2015-07-06通讯作者:陈乃宏，男，博士生导师，教授，研究方向为神经药理学。E-mail: Chennh@imm.ac.cn作者简介:姜懿纳，女，在读硕士；研究方向：神经药理学；E-mail: 443446890@qq.comJIANG Yi-na, CHEN Nai-hong
Online:2015-06-26Published:2015-07-06Contact:陈乃宏，男，博士生导师，教授，研究方向为神经药理学。E-mail: Chennh@imm.ac.cnAbout author:姜懿纳，女，在读硕士；研究方向：神经药理学；E-mail: 443446890@qq.com摘要：帕金森病在全球神经退行性疾病中的发病率中，仅次于阿尔茨海默症。Parkin是帕金森病的相关致病基因之一，自日本学者发现证实其与帕金森病发病相关以来，关于Parkin的研究迅速发展。Parkin的基本结构和生理功能、蛋白底物、相关基因以及其致病机制已被众多文献报道，本文综述了Parkin及蛋白的结构，并对Parkin的泛素-蛋白体酶系统详细介绍，指出了Parkin的相关反应物以及和线粒体的关系，并对其发展前景提出设想。
中图分类号:
姜懿纳, 陈乃宏.帕金森病致病基因Parkin的研究进展[J]. 神经药理学报, 2015, 5(3): 36-45.
JIANG Yi-na, CHEN Nai-hong.Advances in Parkinson’s Disease-Causing Gene Parkin[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 36-45.
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