神经药理学报››2012,Vol. 2››Issue (4): 40-46.
徐媛媛,徐江平
出版日期:
2012-08-26发布日期:
2014-06-27通讯作者:
徐江平,男,教授,博士,博士生导师;研究方向:神经药理与新药临床前评价研究;Tel:+86-020-61648236,E-mail:jpx@smu.edu.cn作者简介:
徐媛媛,女,硕士;研究方向:神经药理学; E-mail:1172660113@qq.com基金资助:
国家自然科学基金(No.81373384)
XU Yuan-yuan , XU Jiang-ping
Online:
2012-08-26Published:
2014-06-27Contact:
徐江平,男,教授,博士,博士生导师;研究方向:神经药理与新药临床前评价研究;Tel:+86-020-61648236,E-mail:jpx@smu.edu.cnAbout author:
徐媛媛,女,硕士;研究方向:神经药理学; E-mail:1172660113@qq.comSupported by:
国家自然科学基金(No.81373384)
摘要:神经生长因子( nerve growth factor,NGF)是神经营养因子的一种,广泛存在于神经组织和周围靶组织。在中枢神经系统,NGF兼有神经营养和促进神经突起生长的效应,从而参与神经细胞的分化、发育和损伤修复过程。近些年的研究表明,视神经节细胞表达包括NGF在内的多种神经营养因子,表达的NGF通过结合于其受体发挥作用,其高亲和力受体(酪氨酸蛋白激酶A受体) 存在于视神经节细胞上,而其低亲和力受体(p75NTR)则在胶质细胞中广泛表达,这些研究提示NGF可能在眼科疾病的治疗中发挥作用,本文就神经生长因子及其受体在眼组织中的表达、对视神经和视网膜损伤的保护、角膜损伤修复以及对青光眼干眼病的治疗进行了阐述。
中图分类号:
徐媛媛,徐江平.神经生长因子对眼科疾病治疗的展望[J]. 神经药理学报, 2012, 2(4): 40-46.
XU Yuan-yuan,XU Jiang-ping.Prospective Overview of Nerve Growth Factor on the Pharmacotherapy of Ophthalmic Diseases[J]. Acta Neuropharmacologica, 2012, 2(4): 40-46.
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