神经药理学报››2014,Vol. 4››Issue (6): 55-64.

• 综述 •上一篇

脑缺血损伤的保护作用机制研究进展

赵薇1, 2, 李方江2, 王树1

  1. 1. 欧宝平台登录 药学系,张家口,075000,中国
    2. 欧宝平台登录 第一附属医院心血管内科,张家口,075000,中国
  • 出版日期:2014-12-26发布日期:2015-01-20
  • 通讯作者:王树,男,副教授,硕士生导师,研究方向:心脑血管损伤研究,Tel: 86-313-4029308,E-mail:wangshu388@163.com
  • 作者简介:赵薇,女,硕士研究生,研究方向:心脑血管损伤研究, E-mail:670734978@qq.com
  • 基金资助:

    河北省科技支撑计划项目(No.07276166), 欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 项目(No. 2010022)

Progress in Understanding the Mechanism of Protective Effects of Cerebral Ischemia Injury

ZHAO Wei, LI Fang-jiang, WANG Shu

  1. 1. Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, Hebei, China
    2. Department of Cardiovascular Medicine, The First Affiliated Hospital, Hebei North University, Zhangjiakou, 075000, Hebei, China
  • Online:2014-12-26Published:2015-01-20
  • Contact:王树,男,副教授,硕士生导师,研究方向:心脑血管损伤研究,Tel: 86-313-4029308,E-mail:wangshu388@163.com
  • About author:赵薇,女,硕士研究生,研究方向:心脑血管损伤研究, E-mail:670734978@qq.com
  • Supported by:

    河北省科技支撑计划项目(No.07276166), 欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 项目(No. 2010022)

摘要:脑缺血性疾病是临床的常见病、多发病,且研究表明脑缺血后的再灌注损伤,危害极大。近年来,国际医学界对脑缺血再灌注的防护工作越来越重视。深入研究脑缺血损伤的保护机制,对脑缺血性疾病治疗靶点的发现,相应治疗药物的开发都具有重要意义。本文就脑缺血损伤的保护作用机制研究进展作一综述。

关键词:,脑缺血损伤,氧自由基,炎症反应,兴奋性氨基酸,细胞凋亡,热休克蛋白,缺血预适应,亚低温

Abstract:Cerebral ischemic disease is a common disease clinically, and frequently-occurring disease. Research shows that there is serious harm after cerebral ischemia reperfusion injury. In recent years, the cerebral ischemia reperfusion protection was laid emphasis on by the international medical circles. It is very significant for the protective mechanism of further research of cerebral ischemia injury, the discovery of cerebral ischemic disease treatment targets, and the development of the corresponding drugs. This review was focused on the research progress in understanding the mechanism of protective effects of cerebral ischemia injury.

Key words:cerebral ischemic injury,oxygen radical,inflammatory response,excitatory amino acid,apoptosis,heat stock protein,ischemical preconditioning,mild hypothermia

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