<strong>脑缺血预处理和脑缺血耐受机制的研究进展</strong>

摘要/Abstract

摘要：脑缺血预处理（cerebral ischemic preconditioning，CIP）是指短暂的、亚致死性的缺血诱导脑组织产生内源性保护机制，可以提高脑组织对缺血的耐受性。这种脑缺血预处理诱导脑组织对后续致死性脑缺血产生迟发性的抵抗能力的现象称为脑缺血耐受（cerebral ischemic tolerance，CIT）。CIP及CIT潜在的神经保护机制涉及NO及NO相关信号通路、兴奋性或抑制性神经递质、炎症因子、腺苷、细胞能量代谢和线粒体、自噬溶酶体的激活、抑制细胞死亡与凋亡、激活DNA修复和自我修复/重塑机制、血管重塑和保护血脑屏障等。通过对CIP及CIT内源性神经保护的机制的深入研究有助于为临床防治缺血缺氧脑病提供新策略。

关键词:脑缺血预处理,脑缺血耐受,一氧化氮,兴奋性氨基酸,炎症因子

Abstract:Cerebral ischemic preconditioning (CIP) demonstrates an endogenous protective mechanism against ischemic injury with a brief sublethal ischemia increases the tolerance of the brain tissue to subsequent ischemia. Cerebral ischemic tolerance refers to a phenomenon of central nervous system adaptation to any subsequent ischemia by CIP. Establishing such a tolerance involved multiple mechanisms: the NO and NO related signaling pathways, excitatory and inhibitory neurotransmitter, inflammation factors, adenosine, cell energy metabolism and mitochondrial, autophagy-lysosome activation, inhibition of cell death and activate DNA repair and self-repair/remodeling mechanism, vascular remodeling and protect the blood brain barrier, etc. A better understanding of the endogenous neuroprotective mechanisms by which CIP and IP protects against cerebral ischemic insults could help us develop new therapeutic and preventive strategies for ischemia anoxic encephalopathy.

Key words:cerebral ischemic preconditioning,cerebral ischemic tolerance,nitric oxide,excitatory amino acid,inflammatory cytokines

王小琴，邹玉安，郭春燕.脑缺血预处理和脑缺血耐受机制的研究进展[J]. 神经药理学报, 2015, 5(2): 30-37.

WANG Xiao-qin, ZOU Yu-an, GUO Chun-yan.Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance[J]. Acta Neuropharmacologica, 2015, 5(2): 30-37.

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脑缺血预处理和脑缺血耐受机制的研究进展

Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance

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