<strong>肾上腺素受体及其信号参与类风湿关节炎神经免疫调节的研究进展</strong>

摘要/Abstract

摘要：类风湿关节炎（rheumatoid arthritis，RA）的病因尚未完全阐明，神经精神因素参与了RA的发病过程，其通过影响下丘脑-垂体-肾上腺素轴、交感神经系统参与对RA的神经免疫调节。肾上腺素受体（adrenergic receptor, AR）是发挥神经免疫调节的关键受体之一，可能在RA的发生、发展过程中发挥重要作用。本综述从AR的分型及特征、AR及其配体在RA中的表达和功能，AR及其信号对RA的关键免疫细胞T、B淋巴细胞的调节等方面做一综述，以期了解AR信号转导在RA中的作用。

关键词:类风湿关节炎,肾上腺素受体,去甲肾上腺素,应激

Abstract:The etiology of rheumatoid arthritis（ RA） has not been fully elucidated，but the mental factors may be involved in the pathogenesis of RA. These factors regulated the immune function of RA by affecting the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system. Adrenergic receptor（ AR） is the key receptors which plays a role on regulating neural immune function，and it may be involved in the occurrence and development of RA. This review
includes the classification and characteristics of AR，its ligand expression and function in RA，and the regulation of AR on the key immune cells，such as T and B lymphocytes，etc. This review will help understand the research progress of AR and its signal in RA.

Key words:rheumatoid arthritis,adrenergic receptor,norepinephrine,stress

中图分类号:

R593.22

吴华勋，魏伟.肾上腺素受体及其信号参与类风湿关节炎神经免疫调节的研究进展[J]. 神经药理学报, 2015, 5(1): 59-64.

WU Hua-xun，WEI Wei.The Research Progress of Adrenaline Receptor and its Signal Involved in the Regulation on Nerve Immunity in Rheumatoid Arthritis[J]. Acta Neuropharmacologica, 2015, 5(1): 59-64.

参考文献

[1] Marije I Koenders, Wim B van den Berg. Novel therapeutic targets in rheumatoid arthritis [J]. Trends Pharmacol Sci, 2015, 36(4):189-195.

[2] Scott I C, Scott D L. Joint counts in inflammatory arthritis[J].Clin Exp Rheumatol, 2014, 32(5 Suppl 85):S-7-12

[3] Jonathan R Danoff, Garrett Moss, Barthelemy Liabaud, et al. Total knee arthroplasty considerations in rheumatoid arthritis[J]. Autoimmune Dis, 2013, 2013:185340.

[4] Masaaki Iwata, Kristie T Ota, Ronald S Duman. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses[J]. Brain Behav Immun, 2013, 31:105-114.

[5] Grekhov R A, Kharchenko S A, Sule?manova G P, et al. Rheumatoid arthritis: psychosomatic aspects[J].Ter Arkh, 2012, 84(12):125-130.

[6] Rampton D S. The influence of stress on the development and severity of immune -mediated diseases[J]. J Rheumatol Suppl, 2011, 88:43-47.

[7] Joshua D Rosenblat, Danielle S Cha, Rodrigo B Mansur, et al. Inflamed moods: A review of the interactions between inflammation and mood disorders[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53C: 23-34.

[8] Kvetnansky R, Lu X, Ziegler M G. Stress-triggered changes in peripheral catecholaminergic systems[J]. Adv Pharmacol, 2013, 68:359-397.

[9] Meier T, Noll-Hussong M. The role of stress axes in cancer incidence and proliferation[J]. Psychother Psychosom Med Psychol, 2014, 64(9-10):341-344.

[10] Frieda A Koopman, Susanne P Stoof, Rainer H Straub, et al. Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis[J]. Mol Med, 2011, 17(9-10):937-948.

[11] Susanna Cotecchia. The α1-adrenergic receptors: diversity of signaling networks and regulation[J]. J Recept Signal Transduct Res, 2010, 30(6):410-419.

[12] Christopher Cottingham, Wang Qin. α2 adrenergic receptor dysregulation in depressive disorders: implications for the neurobiology of depression and antidepressant therapy[J]. Neurosci Biobehav Rev, 2012, 36(10):2214-2225.

[13] John W Calvert, David J Lefer. Role of β-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection[J]. Physiology (Bethesda), 2013, 28(4):216-224.

[14] Zhu W, Woo A Y, Zhang Y, et al. β-adrenergic receptor subtype signaling in the heart: from bench to the bedside[J]. Curr Top Membr, 2011, 67:191-204.

[15] Virginia M Sanders. The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet? [J]. Brain Behav Immun, 2012, 26(2):195-200.

[16] 赵璐, 许建华.肾上腺素能受体信号通路与结直肠癌关系的研究进展[J]. 世界华人消化杂志, 2014, 22(34):5285-5290.

[17] Babol K, B?asiak J. Beta3-adrenergic receptor[J]. Postepy Biochem, 2005, 51(1): 80-87.

[18] 韩启德.肾上腺素受体研究进展[J].生理科学进展, 1995, 26(2): 103-109.

[19] Robert N Spengler, Stephen W Chensue, Giacherio D A, et al. Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro[J]. J Immunol, 1994, 152(6):3024-3031.

[20] Alfred Opolka, Rainer H Straub, Anja Pasoldt, et al. Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis[J].Arthritis Rheum, 2012, 64(3): 729-739.

[21] Rainer H Straub, Firdaus S Dhabhar, Johannes W J Bijlsma, et al. How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis[J]. Arthritis Rheum, 2005, 52(1):16-26.

[22] Lechin F, van der Dijs B, Lechin A, et al. Plasma neurotransmitters and cortisol in chronic illness: role of stress[J]. J Med, 1994, 25(3-4):181-192.

[23] Dwight M Nance, Virginia M Sanders. Autonomic innervation and regulation of the immune system [J]. Brain Behav Immun, 2007, 21(6):736-745.

[24] Denise L Bellinger, Brooke A Millar, Sam Perez, et al. Sympathetic modulation of immunity: relevance to disease[J]. Cell Immunol, 2008, 252 (1-2):27-56.

[25] Wang Shu-peng, Li Gang. The progression of β-adrenergic modulation in sepsis[J]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, 2011, 23(8):505-508.

[26] Caroline Padro, Virginia M Sanders. Neuroendocrine regulation of inflammation[J]. Semin Immunol, 2014, 26(5):357-368.

[27] Maria Stella Lombardi, Kavelaars A, Schedlowski M, et al. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis[J]. FASEB J, 1999, 13(6):715-725.

[28] Wahle M, Neumann R P, Moritz F, et al. Beta2 -adrenergic receptors mediate the differential effects of catecholamines on cytokine production of PBMC[J]. J Interferon Cytokine Res, 2005, 25(7):384-394.

[29] Cheri L Lubahn, Jill A Schaller, Denise L Bellinger, et al. The importance of timing of adrenergic drug delivery in relation to the induction and onset of adjuvant -induced arthritis[J]. Brain Behav Immun, 2004, 18(6):563-571.

[30] Wu Hong, Wei Wei, Song Li-hua, et al. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis[J].Int Immunopharmacol, 2007, 7(5):662-673

[31] Laurel A Grisanti, Andrew P Woster, Julie Dahlman, et al. α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages[J]. J Pharmacol Exp Ther, 2011, 338(2): 648-657.

[32] Rouppe van der Voort C, Kavelaars A, van de Pol M, et al. Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes[J]. J Neuroimmunol, 1999, 95(1-2):165-173.

[33] Rainer H Straub, Peter Härle. Sympathetic neurotransmitters in joint inflammation[J]. Rheum Dis Clin North Am, 2005, 31(1):43-59,

[34] Katsuyuki Mishima, Hitomi Otani, Takatoshi Tanabe, et al. Inagaki C. Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations[J]. Jpn J Pharmacol, 2001, 85(3):214-226.

[35] Lorton D, Bellinger D L, Schaller J A, et al. Altered sympathetic-to-immune cell signaling via β2-adrenergic receptors in adjuvant arthritis[J]. Clin Dev Immunol, 2013, 2013:764395.

[36] Coderre T J, Basbaum A I, Dallman M F, et al. Epinephrine exacerbates arthritis by an action at presynaptic β2-adrenoceptors[J]. Neuroscience, 1990, 34(2):521-523.

[37] Terence J Coderre, Allan I Basbaum, Clyde Helms, et al. High-dose epinephrine acts at alpha2-adrenoceptors to suppress experimental arthritis[J]. Brain Res, 1991, 544(2): 325-328.

[38] Levine J D, Coderre T J, Helms C, et al. Beta 2-adrenergic mechanisms in experimental arthritis[J]. Proc Natl Acad Sci USA, 1988, 85(2):4553-4556.

[39] Anne-Marie Malfait, Angela S Malik, Lilia Marinova-Mutafchieva, et al. The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action[J]. J Immunol, 1999, 162(10):6278-6283.

[40] Harle P, Pongratz G, Straub R H. The sympathetic nervous system stimulates collagen-induced arthritis (CIA) in the induction phase and inhibits CIA in the late effector phase in DBA-1 mice[J]. Arthritis Rheum, 2003, 48:S350.

[41] Yoshiya Tanaka. Pathological mechanisms in rheumatoid arthritis[J].Nihon Rinsho, 2013, 71(7):1147-1152.

[42] Jose U Scher. B-cell therapies for rheumatoid arthritis[J]. Bull NYU Hosp Jt Dis, 2012, 70(3):200-203.

[43] Kohm A P, Sanders V M. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo[J]. Pharmacol Rev, 2001, 53(4):487-525.

[44] Michelle A Swanson, William T Lee, Virginia M Sanders. IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine[J].J Immunol, 2001, 166(1):232-240.

[45] Wahle M, Stachetzki U, Krause A, et al. Regulation of beta2-adrenergic receptors on CD4 and CD8 positive lymphocytes by cytokines in vitro[J]. Cytokine, 2001,16(6):205-209.

[46] Matthew J Loza, Susan Foster, Stephen Peters, et al. Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells[J]. Blood, 2006, 107(5):2052-2060.

[47] Takako Kizaki, Tetsuya Izawa, Takuya Sakurai, et al. Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappa Bactivation through beta-arrestin 2[J]. Immunology, 2008, 124(3): 348-356.

[48] Matteo Martino, Giulio Rocchi, Andrea Escelsior, et al. Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance[J]. Curr Neuropharmacol, 2012, 10(2):97-123.

[49] Hou N, Zhang X, Zhao L, et al. A novel chronic stress -induced shift in the Th1 to Th2 response promotes colon cancer growth[J]. Biochem Biophys Res Commun, 2013, 439(4):471-476.

[50] Marcia G Guereschi, Leandro P Araujo, Juliana T Maricato, et al. Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA -dependent manner[J]. Eur J Immunol, 2013, 43(4):1001-1012.

[51] Xu B Y, Arlehag L, Rantapää-Dahlquist S B, et al. Beta2 Adrenoceptor gene single nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden[J]. Ann Rheum Dis, 2005, 64(5):773-776.

[52] Lukas Bossaller, Achim Rothe. Monoclonal antibody treatments for rheumatoid arthritis[J]. Expert Opin Biol Ther, 2013, 13(9):1257-1272.

[53] Zhang Ji-Hong, Hu Chong-wei, Zhu Yan-zhu, et al. Effects of norepinephrine on immune functions of cultured splenic lymphocytes exposed to aluminum trichloride[J]. Biol Trace Elem Res, 2013, 154(2):275-280.

[54] Yu Xi-chun, Stavros Stavrakis, Michael A Hill, et al. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension[J]. J Am Soc Hypertens, 2012, 6(1):40-47.

[55] Kin N W, Sanders V M. It takes nerve to tell T and B cells what to do[J].J Leukoc Biol, 2006, 79(6):1093-1104.

[56] Botta F, Maestroni G J. Adrenergic modulation of dendritic cell cancer vaccine in a mouse model: role of dendritic cell maturation[J]. J Immunother, 2008, 31(3):263-270.

[57] Ji Hye Yang, Eun Ok Lee, Sang Eun Kim, et al. Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages[J]. Exp Neurol, 2012, 236(2): 199-206.

肾上腺素受体及其信号参与类风湿关节炎神经免疫调节的研究进展

The Research Progress of Adrenaline Receptor and its Signal Involved in the Regulation on Nerve Immunity in Rheumatoid Arthritis

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