神经药理学报››2015,Vol. 5››Issue (3): 17-21.
曹高亚，王新生
出版日期:2015-06-26发布日期:2015-07-06通讯作者:王新生，男，教授，医学博士，硕士研究生导师；研究方向：麻醉药物与POCD的关系；E-mail：wxinsheng1968@sina.com作者简介:曹高亚，女，硕士研究生；研究方向：麻醉药物与POCD的关系；E-mail:xuexiaoya0814@163.com基金资助:
欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 计划项目（120176）
CAO Gao-ya, WANG Xin-sheng
Online:2015-06-26Published:2015-07-06Contact:王新生，男，教授，医学博士，硕士研究生导师；研究方向：麻醉药物与POCD的关系；E-mail：wxinsheng1968@sina.comAbout author:曹高亚，女，硕士研究生；研究方向：麻醉药物与POCD的关系；E-mail:xuexiaoya0814@163.comSupported by:
欧宝平台登录 自然欧宝娱乐-意甲尤文图斯亚洲区域合作伙伴 计划项目（120176）
摘要：术后认知功能障碍（postoperative cognitive dysfunction，POCD）是老年患者术后常见的并发症，多发生于全身麻醉后。影响POCD的相关因素有很多，其中老龄是POCD的首要危险因素。很多研究显示麻醉也是影响POCD的一个重要因素。报道称，麻醉方式对于POCD并无大的影响，而麻醉药物却能够通过很多的机制影响认知功能。其中，吸入麻醉药，尤其是异氟醚和七氟烷的作用机制得到了广泛的研究。相关研究发现，吸入麻醉药对于认知功能的作用与药物浓度有关。使用高浓度吸入麻醉药可以引起学习和记忆功能减弱；而低浓度的吸入麻醉药有缓解β样淀粉酶沉积，促进学习记忆的作用，但其机制需深入的研究。
中图分类号:
曹高亚, 王新生.吸入麻醉与术后认知功能障碍的关系[J]. 神经药理学报, 2015, 5(3): 17-21.
CAO Gao-ya, WANG Xin-sheng.The Correlation Between Inhalation Anesthesia and Postoperative Cognitive Dysfunction[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 17-21.
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