神经药理学报››2015,Vol. 5››Issue (3): 28-35.
郝军荣,沈丽霞
出版日期:
2015-06-26发布日期:
2015-07-06通讯作者:
沈丽霞,女,教授;研究方向:神经药理学;Tel:+86-0313-4029423,E-mail:shenlixiacn@163.com作者简介:
郝军荣,女,讲师;研究方向:神经药理学及相关药物;Tel:+86-0313-4029305,E-mail:haojunrong3@163.com基金资助:
欧宝平台登录 自然科学青年基金项目(No.Q2014030)、河北省自然科学基金项目(No.H2012405016)、欧宝平台登录 创新人才培育基金项目(No.CXRC1325),2013年度欧宝平台登录 校级重大项目(No.ZD201310)
HAO Jun-rong,SHEN Li-xia
Online:
2015-06-26Published:
2015-07-06Contact:
沈丽霞,女,教授;研究方向:神经药理学;Tel:+86-0313-4029423,E-mail:shenlixiacn@163.comAbout author:
郝军荣,女,讲师;研究方向:神经药理学及相关药物;Tel:+86-0313-4029305,E-mail:haojunrong3@163.comSupported by:
欧宝平台登录 自然科学青年基金项目(No.Q2014030)、河北省自然科学基金项目(No.H2012405016)、欧宝平台登录 创新人才培育基金项目(No.CXRC1325),2013年度欧宝平台登录 校级重大项目(No.ZD201310)
摘要:帕金森病(Parkinson’s disease,PD)是与年龄相关的神经系统慢性退行性疾病,主要病理特征为黑质多巴胺能神经元持续变性,其病因和发病机理尚不清楚。蛋白质组学是从整体水平研究蛋白质在不同疾病状态或外界因素作用下的差异表达情况,已成为探索疾病发病机制、疾病诊断和药物治疗最有效的方法,并为PD发病机制的研究、发现PD的诊断标记物和寻找药物治疗新靶点及研制可靠药物提供有力的依据。本文就蛋白质组学在PD研究中对PD细胞和动物模型、发病机制和PD的诊断以及药物治疗研究中的应用进展做一综述。
中图分类号:
郝军荣,沈丽霞.蛋白质组学在帕金森病研究中的应用研究进展[J]. 神经药理学报, 2015, 5(3): 28-35.
HAO Jun-rong,SHEN Li-xia.The Research Progress of Proteomics Used in Parkinson’s Disease[J]. Acta Neuropharmacologica, 2015, 5(3): 28-35.
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