神经药理学报››2015,Vol. 5››Issue (5): 28-33.

• 专题论著 •上一篇下一篇

神经干细胞对胶质瘤发生发展影响的研究进展

罗林明,姜懿纳,陈乃宏

  1. 1.湖南中医药大学,长沙,410007,中国
    2.中国医学科学院药物研究所,北京,100050,中国
  • 出版日期:2015-10-26发布日期:2016-03-03
  • 通讯作者:陈乃宏,男,博士,研究员;研究方向:神经药理学;Tel:+86-010-63165177,E-mail:chennh@imm.ac.cn
  • 作者简介:罗林明,男,硕士研究生;研究方向:神经药理学;E-mail:18773577304@163.com

Research Progress on the Effect of Neural Stem Cells in the Occurrence and Development of Glioma

LUO Lin-ming, JI Yi-na, CHEN Nai-hong

  1. 1. Hunan University of Chinese Medicine, Changsha, 410007, China
    2. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing,100050,China
  • Online:2015-10-26Published:2016-03-03
  • Contact:陈乃宏,男,博士,研究员;研究方向:神经药理学;Tel:+86-010-63165177,E-mail:chennh@imm.ac.cn
  • About author:罗林明,男,硕士研究生;研究方向:神经药理学;E-mail:18773577304@163.com

摘要:神经干细胞具有自我更新、不断增殖及多向分化的特性,以至在胶质瘤的发生和发展中产生重要的影响。胶质瘤的发生和发展是一个多步骤的复杂过程,涉及大量相关基因、转录因子、信号通路及其它们的相关蛋白,还有一些生长因子和酶等表达和调控的改变。

关键词:神经干细胞,胶质瘤干细胞,胶质瘤,起源,胶质瘤发生,发病机制

Abstract:Neural stem cells have the properties of self-renewal,continuous proliferation and multidifferentiation,which play an important role in the occurrence and development of glioma. The occurrence and development of glioma is a complex multi-step process,involving the changes of a number of related genes,transcription factors,signaling pathways and their associated proteins,as well as some growth factors and enzymes in expression and regulation.

Key words:neural stem cells,glioma stem cells,glioma,origin,gliomagenesis,pathogenesis

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