<strong>聚合物胶束载药系统的研究进展</strong>

摘要/Abstract

摘要：聚合物胶束（polymeric micelles）通常由具有两亲性或带有反向电荷的共聚物在水中聚集而成。疏水性嵌段和亲水性嵌段构成胶束的核-壳结构。拥有亲水性外壳以及纳米级粒径（约为10-100nm）的聚合物胶束不仅能够使其不易被网状内皮系统（reticuloendothelial system，RES）识别吞噬，并且可以通过实体瘤的高通透性和滞留效应（enhanced permeability and retention effect，EPR效应）实现药物胶束对癌组织和炎性组织的被动靶向作用。聚合物胶束可以作为抗癌、抗炎、基因治疗药物的载体。本文总结并分析了聚合物胶束的研究进展，包括胶束的分类组成、制备、胶束的特征、药物胶束的释放以及聚合物胶束的应用。

关键词:纳米,聚合物胶束,药物载体

Abstract:Polymeric micelles are composed by copolymers, which are amphiphilic or oppositely charged in the aqueous solution. The hydrophobic and hydrophilic blocks form core and shell structure of the polymeric micelles. The hydrophilic shell and nanoscale particle size (10-100nm) of the polymeric micelles not only escape recognizing and up taking by the reticuloendothelial system (RES), but also passively target cancer and inflammatory tissue by enhanced permeability and retention effect (EPR). Polymeric micelles are the carrier of anti-cancer, anti-inflammatory and gene therapy medicine. In this review, we summarized the progress of the polymeric micelles, including the classification of the polymeric micelles, micelles preparation, characteristics, drug release and the application of the polymeric micelles.

Key words:nanoscale,polymeric micelles,drug carrier

中图分类号:

R944.9

宗蕊, 沈丽霞.聚合物胶束载药系统的研究进展[J]. 神经药理学报, 2015, 5(6): 21-29.

ZONG Rui, SHEN Li-xia.Polymeric Micelles for Drug Delivery[J]. Acta Neuropharmacologica, 2015, 5(6): 21-29.

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聚合物胶束载药系统的研究进展

Polymeric Micelles for Drug Delivery

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