神经药理学报››2011,Vol. 1››Issue (3): 55-64.
• 综述 •上一篇
薛占霞1,彭亮2
出版日期:
2011-06-26发布日期:
2012-06-28通讯作者:
彭亮,女,教授,博士生导师;研究方向:神经药理学;联系电话:+86-24-23256666-5130作者简介:
薛占霞,女,讲师,博士;研究方向:神经药理学;E-mail:xuezhanxia412@163.com基金资助:
国家自然科学基金项目(No.30670651)
XUE Zhan-xia1,PENG Liang2
Online:
2011-06-26Published:
2012-06-28摘要:情感性精神障碍包括抑郁症(又称单向情感精神障碍)和躁郁症(双相情感精神障碍),是最为常见的精神疾病,其发病率高、复发率高,社会危害严重。目前临床上治疗单向情感精神障碍的主要药物是以氟西汀、度罗西汀为代表的5-羟色胺选择性再摄取抑制剂(serotonin-specific reuptake inhibitors,SSRIs)和5-羟色胺/去甲肾上腺素双重再摄取抑制剂(serotonin/norepinephrine dual reuptake inhibitor,SNRIs)。治疗双相情感精神障碍的药物主要有碳酸锂、丙戊酸钠和卡马西平等。目前,关于这些药物的机制研究主要有以下几方面:①SSRIs上调细胞溶质型磷脂酶A2(cytosolic phospholipase A2,cPLA2)、细胞外信号调控激酶(extracellular-signal regulated kinases,ERK)及c-Fos和FosB 基因表达增加;②腺苷酸脱氨酶(adenosine deaminase,ADAR2)介导氟西汀对5-HT2B受体RNA编辑的调节作用;③碳酸锂、丙戊酸钠和卡马西平对cPLA2a基因表达的长期调节作用及碱化细胞的作用。但现存的理论都不能明确解释药物的作用机制,并且有些研究结果仍存在尚待解决的问题。
中图分类号:
薛占霞, 彭亮.情感性精神障碍疾病治疗药物的研究现状[J]. 神经药理学报, 2011, 1(3): 55-64.
XUE Zhan-xia, PENG Liang.Research Status of the Drugs Uesed in the Treatment of Affective Disorders Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(3): 55-64.
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