神经药理学报››2017,Vol. 7››Issue (1): 1-9.DOI:10.3969/j.issn.2095-1396.2017.01.001
• 专家论坛 •下一篇
张力航,殷明
出版日期:
2017-02-26发布日期:
2017-12-01通讯作者:
殷明,男,医学博士,教授;研究方向:神经药理学;Tel: +86-21-34206836, E-mail: myin@sjtu.edu.cn作者简介:
张力航,男,硕士研究生基金资助:
国家自然科学基金项目(No.81471232),上海市科委基金项目(No.14431901400)
ZHANG Li-hang, YIN Ming
Online:
2017-02-26Published:
2017-12-01Contact:
殷明,男,医学博士,教授;研究方向:神经药理学;Tel: +86-21-34206836, E-mail: myin@sjtu.edu.cnAbout author:
张力航,男,硕士研究生Supported by:
国家自然科学基金项目(No.81471232),上海市科委基金项目(No.14431901400)
摘要:近年来有不少研究兴趣聚焦于基于神经干细胞治疗阿尔茨海默病(Alzheimer’s disease,AD)等神经退行性疾病的策略。到目前为止,所谓的再生医学主要集中于用多能胚胎干细胞进行细胞移植治疗。虽然已经有了一些令人激动的研究结果,但胚胎干细胞替代治疗仍然面临一些障碍,包括免疫排斥、突变带来的过度生长、伦理学争论等。代之而起的探索是用小分子化合物直接调制内源性干细胞的命运,已经取得一些结果,但许多涉及神经干细胞与局部小环境的相互作用及神经干细胞特异性信号机制的基础问题有待阐明。对这些问题的研究可能深化对神经干细胞生物学的认识,并促进创新性治疗药物的问世。
中图分类号:
张力航,殷明.小分子化合物影响神经干细胞再生的思考[J]. 神经药理学报, 2017, 7(1): 1-9.
ZHANG Li-hang, YIN Ming.Thinking of Influences of Small Molecules on Neural Stem Cell Neurogenesis[J]. Acta Neuropharmacologica, 2017, 7(1): 1-9.
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