郭童林,王翠,沈丽霞
出版日期:
2017-12-26发布日期:
2017-12-01通讯作者:
沈丽霞,女,教授,博士,研究生导师;研究方向:神经药理学;Tel:+86-0313-4029305,E-mail:shenlixiacn@163.com作者简介:
郭童林,女,硕士研究生;研究方向:药剂学;E-mail:1404171073@qq.com基金资助:
GUO Tong-lin,WANG Cui,SHEN Li-xia
Online:
2017-12-26Published:
2017-12-01Contact:
沈丽霞,女,教授,博士,研究生导师;研究方向:神经药理学;Tel:+86-0313-4029305,E-mail:shenlixiacn@163.comAbout author:
郭童林,女,硕士研究生;研究方向:药剂学;E-mail:1404171073@qq.comSupported by:
摘要:
固体脂质纳米粒(solid lipid nanoparticles,SLN)是由天然存在或人工合成的固态类脂为载体,将药物镶嵌于类脂核或和黏附于类脂表面制备而成的固体胶粒给药系统,粒径在10~1 000 nm 之间。固体脂质纳米粒所用的载体均为无毒或低毒性、生物相容性好、生物可降解的类脂,是20 世纪90 年代初发展起来的新一代亚微粒给药系统。固体脂质纳米粒具有控制药物释放、避免药物的降解或泄漏以及良好的靶向性等优点。该文对固体脂质纳米粒基本组成成分、制备方法、影响载药量(drug loading,DL)和包封率(entrapment efficiency,EE)的因素、载药系统的释放以及固体脂质纳米粒的应用、优势等方面进行综述。
中图分类号:
郭童林,王翠,沈丽霞.固体脂质纳米粒的研究进展[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2017.06.003.
GUO Tong-lin,WANG Cui,SHEN Li-xia.Research Progress of Solid Lipid Nanoparticles[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2017.06.003.
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