神经药理学报››2012,Vol. 2››Issue (2): 32-36.
肖寒贫1,王烁宇2,李华南2,张水印1,顾兵1
出版日期:
2012-04-26发布日期:
2013-11-01通讯作者:
顾 兵,男,博士后,教授,硕士生导师;研究方向:神经精神药物学;E-mail:bguemory@hotmail.com作者简介:
肖寒贫,女,硕士生;研究方向:运动人体科学;E-mail: 444179060@qq.com基金资助:
国家自然科学基金项目(No. 30960448),江西省自然科学基金项目(No. 20114BAB205033),江西省教育厅科技项目(No. GJJ11596、GJJ12584)
XIAO Han-ping1, WANG Shuo-yu2, LI Hua-nan2, ZHANG Shui-yin1, GU Bing1
Online:
2012-04-26Published:
2013-11-01Contact:
顾 兵,男,博士后,教授,硕士生导师;研究方向:神经精神药物学;E-mail:bguemory@hotmail.comAbout author:
肖寒贫,女,硕士生;研究方向:运动人体科学;E-mail: 444179060@qq.comSupported by:
国家自然科学基金项目(No. 30960448),江西省自然科学基金项目(No. 20114BAB205033),江西省教育厅科技项目(No. GJJ11596、GJJ12584)
摘要:脊髓损伤会导致患者相应的运动、感觉和括约肌功能障碍,甚至出现各种并发症。尽管发现不少候选药物具有脊髓神经保护功能,但应用于临床的有效药物极少。绝大多数脊髓损伤药物还是停留在临床前研究阶段。本文重点对已进入临床试验的治疗脊髓损伤的药物进行综述。
中图分类号:
肖寒贫,王烁宇,李华南,张水印,顾兵.脊髓损伤治疗药物的研究现状[J]. 神经药理学报, 2012, 2(2): 32-36.
XIAO Han-ping1, WANG Shuo-yu2, LI Hua-nan2, ZHANG Shui-yin1, GU Bing1.Pharmacotherapies for Spinal Cord Injury: Current Status[J]. Acta Neuropharmacologica, 2012, 2(2): 32-36.
[1] J Marc Simard, Ming-kui Chen, Kirill V Tarasov, et al. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke[J]. Nat Med, 2006, 12(4): 433-440. [2] Toshihiro Takami, Martin Oudega, John R Bethea, et al. Methylprednisolone and interleukin-10 reduce gray matter damage in the contused Fischer rat thoracic spinal cord but do not improve functional outcome [J]. J Neurotrauma, 2002, 19(5): 653- 666. [3] Daniel P Lammertse. Update on pharmaceutical trials in acute spinal cord injury[J]. J Spinal Cord Med, 2004, 27(4): 319-325 [4] Michael B Bracken, Mary J Shepard, William F Collin, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study[J]. N Engl J Med, 1990, 322(20): 1405-1411. [5] Justin P Kubeck, Andrew Merola, Sameer Mathur, et al. End organ effects of high-dose human equivalent methylprednisolone in a spinal cord injury rat model[J]. Spine (Phila Pa 1976), 2006, 31(3): 257-261. [6] Michael B Bracken, Mary Jo Shepard, Theodore R Holford, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial[J]. J Neurosurg, 1998, 89(5): 699-706. [7] Elaine E Tseng, Malcolom V Brock, Mary S Lange, et al. Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest[J]. Surgery, 1998, 124(2): 298-306. [8] 王易虎, 易南, 张灿久. 康复训练加神经节苷脂对脊髓损伤恢复期的治疗作用[J]. 中国临床康复, 2003, 7(26): 3604-3605. [9] Seidl E C. Promising pharmacological agents in the management of acute spinal cord injury[J]. Pharm Pract Manag Q, 2000, 20(1): 21-27. [10] Darryl C Baptiste, Michael G Fehlings. Pharmacological approaches to repair the injured spinal cord[J]. J Neurotrauma, 2006, 23(3): 318-334. [11] Judith B Walker, Michelle Harris. GM-1 ganglioside administration combined with physical therapy restores ambulation in humans with chronic spinal cord injury[J]. Neurosci Lett, 1993, 161(2): 174-178. [12] Fred H Geisler, William P Coleman, Giacinto Grieco, et al. The Sygen multicenter acute spinal cord injury study[J]. Spine (Phila Pa 1976), 2001, 26(24): S87-S98. [13] Michael G Fehlings, Darryl C Baptise. Current status of clinical trials for acute spinal cord injury[J]. J Injure, 2005, 36(l2): B113-B122. [14] Stewart J E, Barbeau H, Gauthier S. Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients[J]. Can J Neurol Sci, 1991, 18(3): 321-332. [15] Rémy-Néris O, Barbeau H, Daniel O, et al. Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects[J]. Exp Brain Res, 1999, 129(3): 433-440. [16] Wainberg M, Barbeau H, Gauthier S. The effects of cyproheptadine on locomotion and on spasticity in patients with spinal cord injuries[J]. J Neurol Neurosurg Psychiatry, 1990, 53(9): 754-763. [17] Fung J, Stewart J E, Barbeau H. The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects[J]. J Neurol Sci, 1990, 100(1-2): 85-93. [18] Kathleen E Norman, Andrew Pépin, Hugues Barbeau. Effects of drugs on walking after spinal cord injury[J]. Spinal Cord, 1998, 36(10): 699-715. [19] Ozerk Okutan, Ihsan Solaroglu, Etem Beskonakli, et al. Recombinant human erythropoietin decreases myeloperoxidase and caspase-3 activity and improves early functional results after spinal cord injury in rats[J]. J Clin Neurosci, 2007, 14(4): 364-368. [20] Anna-Leena Sirén, Theresa Fasshauer, Claudia Bartels, et al. Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system[J]. Neurotherapeutics, 2009, 6(1): 108-127. [21] Hyung Chun Park, Yoo Shik Shim, Yoon Ha, et al. Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granu locyte-macrophage colony stimulating factor[J]. Tissue Eng, 2005, 11(5-6): 913-922. [22] L Jackson II Roberts, John A Oates, MacRae F Linton, et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans[J]. Free Radic Biol Med, 2007, 43(10): 1388-1393. [23] 龚耀成, 梁 裕. 甲钴胺治疗下腰椎疾患: Ⅲ期临床试验[J]. 中国新药与临床杂志,2000, 19(2): 124-126. [24] Segal J L, Brunnemann S R. 4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans[J]. J Spinal Cord Med, 1998, 21(3): 200-204. [25] Jack L Segal, Mayank S Pathak, Jesus P Hernandez, et al. Safety and efficacy of 4-aminopyridine in humans with spinal cord injury: a long-term, controlled trial[J]. Pharmacotherapy, 1999, 19(6): 713-723. [26] van der Bruggen M A, Huisman H B, Beckerman H, et al. Randomized trial of 4-aminopyridine in patients with chronic incomplete spinal cord injury[J]. J Neurol, 2001, 248(8): 665-671. [27] DeForge D, Nymark J, Lemaire E, et al. Effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: a double-blind, placebo-controlled, crossover trial [J]. Spinal Cord, 2004, 42(12): 674-685. [28] Israel Grijalva, Gabriel Guízar-Sahagún, Gilberto Castañeda-Hernández, et al. Efficacy and safety of 4-aminopyridine in patients with long-term spinal cord injury: a randomized, double-blind, placebo-controlled trial[J]. Pharmacotherapy, 2003, 23(7): 823-834. [29] Israel Grijalva, Gabriel Guízar-Sahagún, Delia Rodríguez-Pacheco, et al. Gastric emptying effect by 4-aminopyridine in patients with chronic spinal cord injury[J]. Arch Med Res, 2007, 38(4): 392-397. [30] David J McAdoo, Michael G Hughes, Linghui Nie, et al. The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage --> glutamate release --> damage --> glutamate release --> etc[J]. Brain Res, 2005, 1038(1): 92-99. [31] Darryl C Baptiste, Michael G Fehlings. Update on the treatment of spinal cord injury[J]. Prog Brain Res, 2007, 161: 217-233. [32] Coderre T J, Kumar N, Lefebvre C D, et al. A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain[J]. J Neurochem, 2007, 100(5): 1289-1299. [33] Michael G Fehlings, Jefferson R Wilson, Ralph F Frankowski, et al. Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial[J]. Neurosurg Spine, 2012, 17(1 Suppl): 151-156. [34] Nanna B Finnerup, Fin Biering-Sørensen, Inger L Johannesen, et al. Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial[J]. Anesthesiology, 2005, 102(5): 1023-1030. [35] Alexander G Rabchevsky, Samir P Patel, Joe E Springer. Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward? [J]. Pharmacol Ther, 2011, 132(1): 15-29. [36] Alan I Faden, Thomas P Jacobs, Michael T Smith. Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia[J]. J Neurosurg, 1984; 60(4): 796-799. [37] Diana S L Chow, Yang Teng, Elizabeth G Toups, et al. Pharmacology of riluzole in acute spinal cord injury[J]. J Neurosurg Spine, 2012, 17(1 Suppl): 129-140. [38] 李 明, 叶晓健, 余科炜, 等. 纳洛酮治疗急性脊髓损伤的临床观察[J]. 中国矫形外科杂志, 1997, 4(4): 280-281. [39] Michael B Bracken, Mary J Shepard, William F Jr Collins, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study[J]. J Neurosurg, 1992, 76(1): 23-31. [40] Natasha Olby. Current concepts in the management of acute spinal cord injury[J]. J Vet Intern Med, 1999, 13(5): 399-407. [41] Drug C Baptiste, Allyson Tighe, Michael G Fehlings. Spinal cord injury and neural repair: focus on neuroregenerative approaches for spinal cord injury[J]. Expert Opin Investig Drugs, 2009, 18(5): 663-673. [42] Kopp M A, Liebscher T, Niedeggen A, et al. Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury[J]. Cell Tissue Res, 2012, 349(1): 119-132. [43] Michael G Fehlings, Nicholas Theodore, James Harrop, et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury[J]. J Neurotrauma, 2011, 28(5): 787-796. [44] Brad A Bryan, Emily Dennstedt, Dianne C Mitchell, et al. RhoA/ROCKsignaling is essential for multiple aspects of VEGF-mediatedangiogenesis[J]. FASEB J, 2010, 24(9): 3186-3195. |
[1] | 郭子霞, 安子璇, 张健美, 张丹参.药物治疗溃疡性结肠炎的信号通路研究进展[J]. 神经药理学报, 2020, 10(4): 41-50. |
[2] | 杨旭华, 杜爽, 沈丽霞, 郝军荣.阿尔茨海默病的药物治疗研究进展[J]. 神经药理学报, 2020, 10(3): 47-53. |
[3] | 夏小雯, 宋春红, 乔明琦, 等.经前烦躁障碍症发生机制研究进展[J]. 神经药理学报, 2019, 9(6): 36-40. |
[4] | 龙森,陈嘉烨,韩峰.童年孤独症发病机制及药物治疗进展[J]. 神经药理学报, 2016, 6(6): 55-64. |
[5] | 张 思, 顾 兵, 王烁宇, 李华南, 张国福, 张水印.甲氨蝶呤治疗大鼠脊髓挫伤对急性期脂质过氧化的影响[J]. 神经药理学报, 2014, 4(1): 11-16. |
[6] | 张思,王烁宇,顾兵,李华南,张国福,张水印.低剂量甲氨蝶呤治疗大鼠脊髓挫伤对神经细胞凋亡的影响[J]. 神经药理学报, 2013, 3(6): 1-8. |
[7] | 郝军荣,田玉琴,沈丽霞.神经胶质瘤药物治疗研究进展[J]. 神经药理学报, 2013, 3(3): 48-56. |
[8] | 张思, 顾兵, 李华南, 张国福, 张水印, 闵友江.诱导多能干细胞及其移植治疗脊髓损伤的研究现状[J]. 神经药理学报, 2013, 3(3): 57-64. |
[9] | 郝军荣,沈丽霞.神经胶质瘤药物治疗的中药有效成分研究进展[J]. 神经药理学报, 2012, 2(5): 57-64. |
[10] | 张思,王烁宇, 李华南, 张国福, 顾兵.急性脊髓损伤后的氧化应激及其抗氧化治疗[J]. 神经药理学报, 2012, 2(3): 52-64. |
[11] | 顾兵, 王烁宇, 李华南, 王俊, 张水印.重组人促红细胞生成素与甲基泼尼松龙早期治疗大鼠脊髓挫伤的形态学研究[J]. 神经药理学报, 2011, 1(6): 7-16. |
[12] | 靳淼,安红梅.阿尔茨海默病的动物模型制备及药物治疗[J]. 神经药理学报, 2011, 1(6): 28-36. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||