神经药理学报››2012,Vol. 2››Issue (2): 58-64.
• 综述 •上一篇
赵丽艳1,余秀娟1,韩天云2,张万明1
出版日期:
2012-04-26发布日期:
2013-11-01通讯作者:
张万明,男,教授,硕士生导师,研究方向:神经药理学,中药药理;E-mail: zwm19650228@163.com作者简介:
赵丽艳,女,硕士,助教,E-mail:ahaoli_86@163.com基金资助:
河北省教育厅基金资助项目(No.z2008106);欧宝平台登录 基金资助项目(No.2001017)
Zhao Li-yan1,Yu Xiu-juan1,Han Tian-yun2,Zhang Wan-ming1
Online:
2012-04-26Published:
2013-11-01Contact:
张万明,男,教授,硕士生导师,研究方向:神经药理学,中药药理;E-mail: zwm19650228@163.comAbout author:
赵丽艳,女,硕士,助教,E-mail:ahaoli_86@163.comSupported by:
河北省教育厅基金资助项目(No.z2008106);欧宝平台登录 基金资助项目(No.2001017)
摘要:姜黄素(curcumin)是从姜科姜黄属植物的根茎中提取出来的一种黄色植物多酚,已经有多年应用。姜黄素具有抗炎、抗氧化等多种药理作用,可以改善癌症、糖尿病和脑外伤等多种疾病症状。近年来随着对姜黄素研究的深入,发现在神经系统疾病中也有较好的效果,如阿尔茨海默尔病、帕金森病、神经疼痛和神经系统肿瘤等。本文综述了姜黄素神经保护效应及其机制。
中图分类号:
赵丽艳,余秀娟, 韩天云,张万明.姜黄素的神经保护作用研究进展[J]. 神经药理学报, 2012, 2(2): 58-64.
ZHAO Li-yan1,YU Xiu-juan1,HAN Tian-yun2,ZHANG Wan-ming1.A Review on the Neuroprotective Effects of Curcumin[J]. Acta Neuropharmacologica, 2012, 2(2): 58-64.
[1] Zhao Xin, Xu Ying, Zhao Qing, et al. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved [J]. Neuropharmacology, 2012, 62(2): 843-854. [2] Sudarshana Purkayastha, Alexandra Berliner, Suraj Shawn Fernando, et al. Curcumin blocks brain tumor formation [J]. Brain Res, 2009, 1266: 130-138. [3] Bharat B. Aggarwal, Kuzhuvelil B. Harikumar. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases [J]. Int J Biochem Cell Biol, 2009, 41(1): 40-59. [4] Aynun N Begum, Mychica R Jones, Giselle P Lim, et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease [J]. J Pharmacol Exp Ther, 2008, 326(1): 196-208. [5] 李高文, 徐英, 库宝善, 等. 姜黄素的中枢药理作用研究进展 [J]. 神经药理学报, 2011, 1(2): 48-58. [6] Muh-Shi Lin, Hung Kuo-Sheng, Chiu Wen-Ta, et al. Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35(4): 931-938. [7] Huang Han-Chang, Xu Ke, Jiang Zhao-Feng. Curcumin-mediated neuroprotection against amyloid-β-induced mitochondrial dysfunction involves the inhibition of GSK-3β [J]. J Alzheimers Dis, 2012, 32(4): 981-996. [8] Mansouri Zahra, Sabetkasaei Masoumeh, Moradi Fatemeh, et al. Curcumin has neuroprotection effect on homocysteine rat model of Parkinson [J]. J Mol Neurosci, 2012, 47(2): 234-242. [9] Rajeswari A. Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [J]. Eur Rev Med Pharmacol Sci, 2006, 10(4): 157-161. [10] Rajeswari A, Sabesan M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice [J]. Inflammopharmacology, 2008, 16(2): 96-99. [11] Gulrana Khuwaja, Mohd Moshahid Khan, Tauheed Ishrat, et al. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies [J]. Brain Research, 2011, 1368(12): 254-263. [12] 王晓静, 吴华璞, 李子广, 等. 姜黄素抗脑缺血再灌注损伤作用与MAPK 信号通路的相关性分析[J]. 中西医结合心脑血管病杂志, 2010, 8(6): 711-713. [13] 庄荣, 林孟相, 宋秋英, 等. 姜黄素对大鼠脑缺血再灌注损伤时NF-κB、ICAM-1的影响[J]. 南方医科大学学报, 2009, 29(6): 1153-1155. [14] 武静茹, 张励才, 李军, 等. 姜黄素对大鼠脑缺血再灌注损伤的保护作用[J]. 山东医药, 2007, 47(16): 24-25. [15] 徐芳, 魏桂荣. 姜黄素对脑缺血再灌注模型大鼠的神经保护作用及其机制[J]. 微循环学杂志, 2011, 21(3): 17-18. [16] 秦怀洲, 张治国, 吴琳, 等. 姜黄素对人神经母细胞瘤细胞作用的体外试验研究[J]. 中国药房, 2012, 23(15): 1367-1369. [17] Wayne S. Orr, Jason W. Denbo, Karim R. Saab, et al. Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition [J]. Surgery, 2012, 151(5): 736-744. [18] Tae Hyung Kim, Hai Hua Jiang, Yu Seok Youn, et al. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity [J]. Int J Pharm, 2011, 403(1-2): 285-291. [19] Navneet Dhillon, Bharat B Aggarwal, Robert A Newman, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer [J]. Clin Cancer Res, 2008, 14(14): 4491-4499. [20] Bayet-Robert Mathilde, Kwiatkowski Fabrice, Leheurteur Marianne, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer [J]. Cancer Biol Ther, 2010, 9(1): 8-14. [21] Rohit S. Mulik, Jukka Mönkkönen, Risto O. Juvonen, et al. ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells [J]. Int J Pharm, 2012, 437(1-2): 29-41. [22] Matthew S Squires, E Ann Hudson, Lynne Howells, et al. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells [J]. Biochem Pharmacol, 2003, 65(3): 361-376. [23] Ruby John Anto, Asok Mukhopadhyay, Kate Denning, et al. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl [J]. Carcinogenesis, 2002, 23(1): 143-150. [24] 秦怀洲, 张治国, 吴琳, 等. 姜黄素对人神经母细胞瘤细胞作用的体外试验研究[J]. 中国药房, 2012, 23(15): 1367-1369. [25] Jyoti Nautiyal, Sanjeev Banerjee, Shailender S Kanwar, et al. Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells [J]. Int J Cancer, 2011, 128(4): 951-961. [26] Adriana Monserrath Orellana-Paucar, Ann-Sophie K. Serruys, Tatiana Afrikanova, et al. Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models[J]. Epilepsy Behav, 2012, 24(1): 14-22. [27] Neveen A. Noor, Heba S. Aboul Ezz, Abdel Razik Faraag, et al. Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate [J]. Epilepsy Behav, 2012, 24(2): 199-206. [28] K.H. Reeta, Jogender Mehla, Monika Pahuja, et al. Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats [J]. Pharmacol Biochem Behav, 2011, 99(3): 399-407. [29] 孟伟, 杨锦青, 鞠培新, 等. 姜黄素对癫痫小鼠海马脑损伤的保护作用[J]. 解剖科学进展, 2012, 18(4): 323-325. [30] 黄志凌, 肖波, 王蓉, 等. 姜黄素对癫痫持续状态后海马内质网应激相关分子表达的影响[J]. 中国神经免疫学和神经病学杂志, 2007, 14(3): 141-145. [31] 黄志凌, 肖波, 谭利明, 等. 姜黄素对癫痫持续状态致大鼠海马神经元程序化死亡的影响[J]. 中国康复医学杂志, 2006, 21(7): 590-592. [32] Jogender Mehla, K.H. Reeta, Pooja Gupta, et al. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model [J]. Life Sci, 2010, 87(19-22): 596-603. [33] Nidhi Bharal Agarwal, Seema Jain, Nitin K. Agarwal, et al. Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice[J]. Phytomedicine, 2011, 18(8-9): 756-759. [34] Amar Jyoti, Pallavi Sethi, Deepak Sharma. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis [J]. Epilepsy Behav, 2009, 14(2): 300-308. [35] 李旭, 曹红, 连庆泉, 等. p-ERK、p-CREB、c-fos在姜黄素抗大鼠神经病理性痛中的作用[J]. 中国应用生理学杂志, 2009, 25(3): 418-422. [36] 郑晋伟, 郑昌健, 曹红, 等. 姜黄素下调神经病理性疼痛大鼠脊髓背角和背根节CX3CR1的表达[J]. 中国中药杂志, 2011, 36(18): 2252-2256. [37] Rayanta P. Joshi, Geeta Negi, Ashutosh Kumar, et al. SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: An insight into its mechanism for neuroprotection[J]. Nanomedicine, 2013, 9(6): 776-785. [38] Thomas L. Perry, Voon Wee Yong. Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients [J]. Neurosci Lett, 1986, 67(3): 269-274. [39] G. Harish, C. Venkateshappa, Rajeswara Babu Mythri, et al. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease [J]. Bioorg Med Chem, 2010, 18(7): 2631-2638. [40] Iván Carmona-Ramírez, Abel Santamaría, Julio C. Tobón-Velasco, et al. Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity [J]. J Nutr Biochem, 2013, 24(1): 14-24. [41] Xu Ying, Li Shan, Matthew M Vernon, et al. Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway [J]. J Neurochem, 2011, 118(5): 784-795. [42] Kumar P, Padi S S V, Naidu P S, et al. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity [J]. Methods Find Exp Clin Pharmacol, 2007, 29(1): 19-25. [43] Daniel Sheril, Janice L Limson, Amichand Dairam, et al. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain [J]. J Inorg Biochem, 2004, 98(2):266-275. [44] Rajesh S. Yadav, Rajendra K. Shukla, Madhu Lata Sankhwar, et al. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats [J]. Neurotoxicology, 2010, 31(5): 533-539. [45] Opa Vajragupta, Preecha Boonchoong, Hiroshi Watanabe, et al. Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity [J]. Free Radic Biol Med, 2003, 35(12): 1632-1644. [46] Opa Vajragupta, Preecha Boonchoong, Lawrence J Berliner. Manganese complexes of curcumin analogues: evaluation of hydroxyl radical scavenging ability, superoxide dismutase activity and stability towards hydrolysis [J]. Free Radic Res, 2004, 38(3): 303-314. [47] Yaowared Sumanont, Yukihisa Murakami, Michihisa Tohda, et al. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin [J]. Life Sci, 2006, 78(16): 1884-1891. [48] Zhao Li-yan, Du Jian-chao, Duan Yu-wei, et al. Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization [J]. Colloids and Surfaces B: Biointerfaces, 2012, 97(1): 101-108. [49] Song Zhi-mei, Feng Run-liang, Sun Min, et al. Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo [J]. J Colloid Interface Sci, 2011, 354(1): 116-123. [50] Zhang Lin, Zhu Wei-wei, Yang Chun-fen, et al. A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting [J]. Int J Nanomedicine, 2012, 7:151-162. [51] Jing Cui, Bo Yu, Yu Zhao, et al. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems [J]. Int J Pharm, 2009, 371(1-2): 148-155. [52] Sun Min, Gao Yan, Guo Chen-yu, et al. Enhancement of transport of curcumin to brain in mice by poly (n-butylcyanoacrylate) nanoparticle [J]. J Nanopart Res, 2010, 12 (8): 3111-3122. [53] Wang Shuang, Chen Ping, Zhang Lin, et al. Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin [J]. J Drug Target, 2012, 20(10): 831-840. |
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