<strong>Parkinson Associated DJ-1 Gene and Oxidative Stress</strong>

Abstract

Abstract:Parkinson’s disease is characterized by the substantia nigra pars compacta dopaminergic neuron-specific death and the presence of eosinophilic inclusion bodies-Lewy bodies which’s main component is α- synuclein in residual neuronal. Recent studies show that oxidative stress is a leading cause of brain dopaminergic neuron-specific death. DJ-1 （Park7） gene is an autosomal recessive Parkinson’s disease related genes. DJ-1 protein has a strong antioxidant effect，mainly acts as identity of active oxygen scavenger，chaperones，signaling pathways regulating molecules to against the oxidative stress，thereby protecting dopamine neurons from damage. Both deletion and mutation of DJ-1 gene will cause the reduction of its anti-oxidative stress，resulting in neuronal death，and this situation may be rescued by overexpression of DJ-1 protein. Because of the important role of DJ-1 in the development and occurrence of Parkinson’s disease，the paper will expand on its review of new research，and discuss primarily from the relationship between DJ-1 and oxidative stress.

Key words:Parkinson&,rsquo,s disease（PD）,DJ-1,oxidative stress,reactive oxygen species（ROS）

CLC Number:

R964

LOU Yu-xia, ZHANG Zhao, WANG Zhen-zhen, JIANG Yi-na, ZHANG Yi, LI Lin, CHEN Nai-hong.Parkinson Associated DJ-1 Gene and Oxidative Stress[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(1): 58-64.

References

[1] Ana Clara Cristovao, Dong-Hee Choi, Graca Baltazar, et al. The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death[J]. Antioxid Redox Signal, 2009, 11(9): 2105-2118.

[2] Johanna Mäkelä, Timofey V Tselykh, Jyrki P Kukkonen, et al. Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons[J]. Neuropharmacology, 2016, 102: 266-275.

[3] Nirit Lev, Yael Barhum, Neri S Pilosof, et al. DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging[J]. J Gerontol A Biol Sci Med Sci, 2013, 68(3): 215-225.

[4] Alvin P Joselin, Sarah J Hewitt, Steve M Callagham, et al. ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons[J]. Hum Mol Genet, 2012, 21(22): 4888-4903.

[5] Kazuki Hattori, Isao Naguro, Christopher Runchel, et al. The roles of ASK family proteins in stress responses and diseases[J]. Cell Commun Signal, 2009, 7: 9.

[6] Jens Waak, Stephanie Weber, Karin Gorner, et al. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1[J]. J Biol Chem, 2009, 284(21): 14245-57.

[7] Xiao Tao, Liang Tong. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease[J]. J Biol Chem, 2003, 278(33): 31372-31379.

[8] Olga Corti, Suzanne Lesage, Alexis Brice. What genetics tells us about the causes and mechanisms of Parkinson's disease[J]. Physiol Rev, 2011, 91(4): 1161-1218.

[9] Hiromasa Ooe, Chinatsu Maita, Hiroshi Maita, et al. Specific cleavage of DJ-1 under an oxidative condition[J]. Neurosci Lett, 2006, 406(3): 165-168.

[10] Chen Jue, Li Lian, Chin Lih-shen. Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage[J]. Hum Mol Genet, 2010, 19(12): 2395-2408.

[11] N Kotaria, U Hinz, S Zechel, et al. Localization of DJ-1 protein in the murine brain[J]. Cell Tissue Res, 2005, 322(3): 503-507.

[12] Junn Eunsung, Won Hee Jang, Zhao-xin, et al. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection[J]. J Neurosci Res, 2009, 87(1): 123-129.

[13] V Bonifati, P Rizzu, F Squitieri, et al. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism[J]. Neurol Sci, 2003, 24(3): 159-160.

[14] Vincenzo Bonifati, Patrizia Rizzu, Marijke J Van Baren, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism[J]. Science, 2003, 299(5604): 256-259.

[15] Joungil Choi, M Cameron Sullards, James A Olzmann, et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases[J]. J Biol Chem, 2006, 281(16): 10816-10824.

[16] Dong Hwan Ho, Sanghak Yi, Hyemyung Seo, et al. Increased DJ-1 in urine exosome of Korean males with Parkinson's disease[J]. Biomed Res Int, 2014, 2014:704678.

[17] Kang Wen-yan, Yang Qiong, Jiang Xu-feng, et al. Salivary DJ-1 could be an indicator of Parkinson's disease progression[J]. Front Aging Neurosci, 2014, 6: 102.

[18] Masaaki Waragai, Masaaki Nakai, Jianshe Wei, et al. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease[J]. Neurosci Lett, 2007, 425(1): 18-22.

[19] Yoshiro Saito. Oxidized DJ-1 as a possible biomarker of Parkinson's disease[J]. J Clin Biochem Nutr, 2014, 54(3): 138-144.

[20] W Davis Parker, Janice K Parks, Russell H Swerdlow. Complex I deficiency in Parkinson's disease frontal cortex[J]. Brain Res, 2008, 1189: 215-218.

[21] C W Olanow. The pathogenesis of cell death in Parkinson's disease--2007[J]. Mov Disord, 2007, 22(Suppl 17): S335-S342.

[22] P Jenner. Oxidative stress in Parkinson's disease and other neurodegenerative disorders[J]. Pathol Biol (Paris), 1996, 44(1): 57-64.

[23] Philipp J Kahle, Jens Waak, Thomas Gasser. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders[J]. Free Radic Biol Med, 2009, 47(10): 1354-1361.

[24] Hiroyoshi Ariga, Kazuko Takahashi, Izumi Kato, et al. Neuroprotective function of DJ-1 in Parkinson's disease[J]. Oxid Med Cell Longev, 2013, 2013: 683920.

[25] Rosa M Canet-Aviles, Mark A Wilson, David W Miller, et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization[J]. Proc Natl Acad Sci USA, 2004, 101(24):9103-9108.

[26] Eunsung Junn, Hiroyuki Taniguchi, Byeong Seon Jeong, et al. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death[J]. Proc Natl Acad Sci USA, 2005, 102(27): 9691-9696.

[27] Liu Fang, Jamie L Nguyen, John D Hulleman, et al. Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease[J]. J Neurochem, 2008, 105(6): 2435-53.

[28] Zhou Wen-bo, Curt R Freed. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity[J]. J Biol Chem, 2005, 280(52): 43150-43158.

[29] Derek A Drechsel, Manisha Patel. Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system[J]. J Biol Chem, 2010, 285(36): 27850-27858.

[30] Pamela Lopert, Manisha Patel. Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption[J]. Redox Biology, 2014, 2:667-672.

[31] Casey M Clements, Richard S McNally, Brian J Conti, et al. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2[J]. Proc Natl Acad Sci USA, 2006, 103(41):15091-15096.

[32] Melba C Jaramillo, Donna D Zhang. The emerging role of the Nrf2-Keap1 signaling pathway in cancer[J]. Genes Dev, 2013, 27(20): 2179-2191.

[33] Li Gan, Delinda A Johnson, Jeffrey A Johnson. Keap1-Nrf2 activation in the presence and absence of DJ-1[J]. Eur J Neurosci, 2010, 31(6): 967-977.

[34] Tatsuki Yasuda, Yusuke Kaji, Tomohiro, et al. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress[J]. Biochem Biophys Res Commun, 2013, 436(2):289-294.

[35] David Seo, Goldschmidt-Clemont P. The paraoxonase gene family and atherosclerosis[J]. Free Radic Biol Med, 2005, 38(2):153-163.

[36] Lucio G Costa, Rian de Laat, Khoi Dao, et al. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection[J]. Neurotoxicology, 2014, 43: 3-9.

[37] Jagan Mohan Jasna, Kannadasan Anandbabu, Subramaniam Rajesh Bharathi, et al. Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult[J]. PLoS One, 2014, 9(6):e101380.

[38] Mohammad Parsanejad, Noam Bourquard, Dianbo Qu, et al. DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress[J]. PLoS One, 2014, 9(9): e106601.

[39] Rob M Ewing, Peter Chu, Fred Elisma, et al. Large-scale mapping of human protein-protein interactions by mass spectrometry[J]. Mol Syst Biol, 2007, 3(1):89.

[40] M D P Willcox, M Parsanejad, D W S Harty, et al. Regulation of the VHL/HIF-1 pathway by DJ-1[J]. J Neurosci, 2014, 34(23): 8043-8050.

[41] Xiong Ran, Wang Zhi-quan, Zhao Zong-bo, et al. MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration[J]. Neurobiol Aging, 2014, 35(3): 705-714.

Parkinson Associated DJ-1 Gene and Oxidative Stress

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