<strong>Study on the Therapeutic Effect of Traditional Chinese Medicine Compound on Alzheimer’s Disease</strong>

Acta Neuropharmacologica››2016,Vol. 6››Issue (5): 29-33.DOI:10.3969/j.issn.2095-1396.2016.05.004

Study on the Therapeutic Effect of Traditional Chinese Medicine Compound on Alzheimer’s Disease

DONG Yun-fang，WANG Peng-wen

1. Key Laboratory of Chinese Internal Medicine，Beijing University of Chinese Medicine，Ministry of Education，Beijing，100700，China
2. Institute of Neurodegenerative Disease，Beijing University of Chinese Medicine，Beijing，100700，China

Online:2016-10-26Published:2017-01-03
Contact:王蓬文，女，博士，教授，博士生导师；研究方向：神经变性病的中医药防治；Tel：+86-01084013195，E-mail：pw_wang@163.com
About author:董云芳，女，硕士研究生；研究方向：神经变性病的中医药防治；E-mail：535128801@qq.com
Supported by:

国家自然科学基金面上资助项目（No.81573927），北京中医药大学在读研究生项目（No.2016-JYB-XS142）

Abstract

Abstract:Alzheimer's disease （AD） is the most common type of dementia. The incidence of AD increases year by year with the increase in the elderly population，and its mortality，morbidity and high cost of treatment are not only for patients themselves but also for their families members，caregivers and society to bring a heavy financial burden and care burden.But its pathological mechanism is complex，and the lack of effective treatment，and traditional Chinese medicine on the disease has a unique therapeutic advantage. This paper summarizes the related symptoms of AD the intervention and therapeutic effect of traditional chinese medicine compound preparation on various pathogenesis of AD in recent years. The results show that traditional chinese medicine compound preparation is an effective means to treat AD.

Key words:traditional Chinese medicine compound,Alzheimer's disease

DONG Yun-fang，WANG Peng-wen.Study on the Therapeutic Effect of Traditional Chinese Medicine Compound on Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2016, 6(5): 29-33.

References

[1]Joseph D Jebelli, Thomas M Piers. Amyloid-βoligomers unveil a novel primate model of sporadic Alzheimer's disease[J].Front Neurosci. 2015, 9: 47.

[2]Alzheimer A. Uber Einen eigenartigen schweren Erkrankungsprozeb der Hirnrinde[J]. Neurologisches cenrealblatt, 1906, 23, 1129-1136.

[3]董贤慧,柴锡庆.阿尔茨海默病发病机制研究进展[J].中国老年学杂志, 2014, 34(20): 5906-5912.

[4]毕丹蕾, 文朗, 熊伟, 等. 阿尔茨海默病的可能药物靶点和临床治疗研究进展[J].中国药理学与毒理学杂志, 2015, 29(4): 507-532.

[5]王涛涛, 程娟. 传统中药对阿尔茨海默病干预作用的研究进展[J].安徽医科大学学报, 2014, 49(3): 416-419.

[6]Domenico Praticò. Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows[J].Ann N Y Acad Sci, 2008, 1147: 70-78.

[7]M Ramkumar K, V Sekar T, Bhakkiyalakshmi E, et al. The impact of oxidative stress on islet transplantation and monitoring the graft survival by non-invasive imaging[J]. Current Medicinal Chemistry, 2013, 20(9): 1127-1146.

[8]Alessandra Napolitano, Paola Manini, Marco DIschia. Oxidation chemistry of catecholamines and neuronaldegeneration: an update[J]. Current medicinal chemistry, 2011, 18(12): 1832-1845.

[9]Dasuri K, Zhang L, Keller J N．Oxidative stress neurodegeneration and the balance of protein degrad ationandproteinsynthesis[J].FreeRadicBiol Med,2012,62:170-185.

[10]刘瑾, 刘永伟, 李岩, 等. 桑椹补脑膏对东莨菪碱所致记忆获得障碍小鼠学习记忆能力影响[J].辽宁中医药大学学报, 2015, 17(1): 22-24.

[11]李桂琼, 柯大智. 参附注射液对β淀粉样蛋白所致阿尔茨海默病大鼠认知行为和脑组织氧化应激的影响[J].重庆医学, 2010, 39(2): 156-158.

[12]李虹. 补脾益肾汤治疗阿尔茨海默病35例[J].中国实验方剂学杂志, 2015, 21(5): 193-196.

[13]陈烈, 黄君英, 薛俐. 复方何首乌浸膏治疗阿尔茨海默病的疗效研究[J].中南大学学报, 2010, 35(6): 612-614.

[14]Azadeh Karami, Helga Eyjolfsdottir, Swetha Vijayaraghavan, et al. Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease[J].Alzheimers Dement, 2015, 9. pii: S1552-5260.

[15]周爱玲, 茅家慧, 朱燕, 等. 中药复方脑益康干预阿尔茨海默病模型小鼠脑组织神经生长因子及脑源性神经营养因子mRNA的表达[J].中国临床康复, 2006, (31): 16-18.

[16]Wu Yuan-yuan, Wang Xiong, Tan Lan, et al. Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3 and preservation of postsynaptic components[J].J Alzheimers Dis, 2013,37(3):515-27.

[17]田金洲, 徐意, 盛树力, 等. 金思维提取物对AD模型大鼠海马神经元ChAT和NGF表达的影响[J].中医脑病杂志, 2006, 2(l): 202-205.

[18]徐意, 田金洲, 盛树力, 等. 金思维对Alzheimer病模型大鼠学习记忆障碍的改善作用及其机制[J].中华中医药杂志, 2006, 21(4 ):216-219.

[19]聂志玲, 周小莉, 晁利芹. 补肾活血化痰方对阿尔茨海默病模型大鼠海马细胞外调节蛋白激酶1蛋白激酶2蛋白表达的影响[J].河南中医, 2015, 35(1): 47-49.

[20]Huang Shu-ming, Akihiro Mouri, Hideko Kokubo, et al. Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function[J].J Biol Chem, 2006, 281(26): 17941-51.

[21]张雷明, 田金洲, 尹军祥, 等. 中药复方金思维对APPV717I转基因小鼠海马神经损伤的保护作用[J].中草药, 2009, 40(3): 410-415.

[22]尹龙, 田金洲, 时晶, 等. 中药金思维对APPV717I转基因小鼠早期学习记忆能力和CaMKⅡ表达水平的影响[J].中华中医药杂志, 2011, 26(8): 1822-1825.

[23]聂志玲, 周小莉. 寿尔智胶囊对AD模型大鼠突触超微结构的影响[J].湖北中医杂志, 2014, 36(11): 18-19.

[24]Nazneen N Dewji, S Jonathan Singer, Eliezer Masliah, et al. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approACh to reduce ß-amyloid in Alzheimer's disease[J].PLoS One, 2015, 10(4):e0122451.

[25]邢颖, 张兰, 李林. 参乌胶囊抑制阿尔茨海默病模型小鼠脑内β-淀粉样肽生成的机制研究[J].中国老年学杂志, 2006, 7(26): 924-926.

[26]覃仁安, 罗佳波, 黄竹英. 复方丹参片对阿尔茨海默病大鼠学习记忆障碍和脑组织β-AP含量的影响[J].中华中医药杂志, 2005, 20(6): 377-378.

[27]温世荣, 王德生, 张景艳, 等. 复智散对淀粉样β蛋白25-35神经细胞毒性效应的影响及其机制[J].中国临床康复, 2005, 9(13): 248-249.

[28]Steven Moore, Lewis D B Evans, Therese Andersson, et al. APP metabolism regulates tau proteostasis in human cerebral cortex neurons[J].Cell Rep, 2015, 11(5):689-696.

[29]胡慧, 王平, 孔明望. 补肾化痰方药对阿尔茨海默病模型大鼠脑组织钙/钙调素依赖的蛋白激酶Ⅱ-α活性的影响[J].中华中医药杂志, 2010, 25(5): 786-788.

[30]陈娟, 李宏莲, 王建枝, 等. cdk-5过度表达对Tau蛋白磷酸化的影响[J].中国组织化学与细胞化学杂志, 2004, 13(2): 175-178.

[31]张洪, 许旌, 杨帆. 补肾健脾方对阿尔茨海默大鼠脑组织中cdk-5/p35表达的影响[J].江苏医药, 2010, 36(12): 1407-1410.

[32]李雪娜, 李向军, 王宏涛, 等. 益智胶囊对阿尔茨海默病大鼠学习记忆能力的改善作用[J]. 中国实验方剂学杂志, 2015, 21(5): 115-119.

[33]Zhang F, Jiang L. Neuroinflammation in Alzheimer's disease[J].Neuropsychiatr Dis Treat, 2015, 11: 243-56.

[34]周志昆, 曾红兵, 黄兆胜. 补肾活血方对阿尔茨海默病模型大鼠脑内胶质细胞的影响[J].中国中医基础医学杂志, 2005, 11(6): 425-427.

[35]杨长生, 吴红彦, 李海龙, 等.黑逍遥散对阿尔茨海默病模型大鼠行为学及血清肿瘤坏死因子α及白细胞介素-6和-1β的影响[J].西部中医药, 2015, 28 (2):11-12.

Study on the Therapeutic Effect of Traditional Chinese Medicine Compound on Alzheimer’s Disease

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles0

Recommended Articles

Metrics