<strong>Progress on Research of 5-Lipoxygenase in Alzheimer’s Disease</strong>

Abstract

Abstract:5-lipoxygenase plays a key role in catalyzing the conversion of arachidonic acid （AA） to 5-hydroperoxy-6，8，11，14-eicosatetraenoic acid （5-HPETE），which can then be metabolized into different leukotrienes （LTs）. The recently studies have shown that 5-lipoxygenase is involved in the pathophysiology of Alzheimer’s disease. Inhibition of 5-lipoxygenase decreases amyloid β peptide （Aβ） and tau hyperphosphorylation，mitigates neuroinflammation，regulates synaptic function and ameliorates cognitive disorders in Alzheimer’s disease. In this review，we will summarize studies of 5-lipoxygenase in Alzheimer’s disease pathogenesis.

Key words:Alzheimer&,rsquo,s disease,5-lipoxygenase,&,beta,-amyloid peptide,tau,neuroinflammation

DU Guan-tao，ZHANG Chun-teng，HONG Hao.Progress on Research of 5-Lipoxygenase in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2016, 6(5): 39-44.

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Progress on Research of 5-Lipoxygenase in Alzheimer’s Disease

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