<strong>Progress in Genetic Factors for Male Infertility</strong>

Abstract

Abstract:Male infertility was caused by mutiple factors，including both genetic and environmental factors. Nearly 50% of clinic male infertility disorders were from genetic defects，which had shown mainly four different variation hierarchies，aneuploid chromosome variation，structural chromosome variation，gene copy number variation and single gene mutation. In recent years the increasingly deep recognition of genetic male infertility has been witnessed. This review summarizes the research progress of the genetic factors for male infertility on the aspects of epidemiology，mechanisms and pathological changes，from aforesaid four different variations.

Key words:male infertility,genetic defect,chromosome variation,gene copy number variation,single gene mutation

CHEN Wen-yang, SHEN Li-xia, ZHANG Gui-rong.Progress in Genetic Factors for Male Infertility[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(5): 53-64.

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Progress in Genetic Factors for Male Infertility

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