<strong>Advance of Functional Magnetic Resonance Imaging of Brain in Alzheimer’s Disease</strong>

Abstract

Abstract:Alzheimer’s disease （AD） is a commom neurodegenerative disorder in the elderly， which mainly manifeste cognitive function， behavioral and psychological symptoms，and activities of daily living. Structue imaging technology is mainly used for measuring the brain structure， which provides support for the diagnosis of AD， but structural imaging of early stage Alzheimer’s disease has no characteristic changes， and it has low sensitivity and specificity for AD diagnosis. However， functional magnetic resonance imaging （fMRI） of brain can compensate for structural imaging technology， and explore the mechanism of pathophysiological of AD. In this paper， we reviewed the functional imaging methods for studying AD nowdays， such as， blood oxygen level dependent functional magnetic resonance imaging （BOLD-fMRI）and diffusion-weighted imaging （DWI）， diffusion tensor imaging （DTI）， magnetic resonance spectroscopy（ MRS） and resting state fMRI（ RS-fMRI）， and so on.

Key words:Alzheimer&rsquo,s disease（AD）,magnetic resonance imaging,structural imaging,functional imaging

CLC Number:

R964

BAI Yan-chang，JIA Yan-li，SONG Ya-xue，WANG Jian-hua.Advance of Functional Magnetic Resonance Imaging of Brain in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(3): 6-11.

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Advance of Functional Magnetic Resonance Imaging of Brain in Alzheimer’s Disease

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