<strong>The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease</strong>

Abstract

Abstract:

Along with aggravation of aging of population，the incidence of Alzheimer’s disease is getting higher and higher. However，etiological treatment of this disease is still unsatisfying. In recent years，the role of gut flora in the pathogenesis of AD has received more and more attention. Types and ratios of gut flora change along with the growth of the age，and the variety of quantities of metabolites makes a difference in the cognitive behavior. Besides，gut flora interacts with gut-brain axis. Nowadays，we have confirmed the role of gut flora in mechanisms of the pathogenesis of AD，including amyloidosis，hyperphosphorylation of tau protein，neuro-inflammation，oxidative stress damage，increase of the permeability of the bloodbrain barrier neurotransmitter imbalance and insulin resistance. In the future，specific regulation of pathogenesis-related gut bacteria will be an important research area.

Key words:gut flora,Alzheimer’s disease,mechanisms of pathogenesis

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R964

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LIU Nuo，WANG Zhen-zhen，CHEN Nai-hong.The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2017.05.005.

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URL:http://actanp.hebeinu.edu.cn/EN/10.3969/j.issn.2095-1396.2017.05.005

http://actanp.hebeinu.edu.cn/EN/Y2017/V7/I5/28

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The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease

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