Acta Neuropharmacologica

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Neurotoxicity and Prevention of Local Anesthetics in Central Nervous System

XING Yuan,ZHANG Nan,ZHANG Wei,REN Lei-ming

  1. Institute of Chinese Integrative Medicine,Hebei Medical University,Shijiazhuang,05000,China
  • Online:2018-06-26Published:2018-11-16
  • Contact:张炜,女,教授;研究方向:神经药理学;E-mail:weizhang@hebmu.edu.cn 任雷鸣,男,教授;研究方向:神经药理学、心血管药理学;E-mail:ren-leiming@263.net
  • About author:邢媛,女,河北医科大学药理学博士研究生
  • Supported by:
    国家自然科学基金项目(No.81573416)

Abstract:

Local anesthetics (LAs) are widely used for caudal,epidural and spinal anesthesia. These drugs manage acute and chronic pain rapidly,however,they are markedly cytotoxic,especially in central nervous system and cardiovascular system. The toxic effects of LAs are dependent on time/dose and usually varies from each other. Recently,many researches focus on the neurotoxicity of LAs. Therefore,we reviewed the neurotoxicity of LAs and prevention of their neurotoxicity.

Key words:local anesthetics,neurotoxicity,neurons,astrocytes,treatments of neurotoxicity

CLC Number:

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