Comparison of Analgesic Effects of Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan on Rats with Neuropathic Pain#br#

Abstract

Abstract:

Objective：To compare the analgesic effects of Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan on chronic neuropathic pain in rats with sciatic nerve chronic constriction injury （CCI）. Methods：The male SD rats were randomly divided into 6 groups，sham operation group （n=13），saline group （n=13），Corydalis Yanhusuo group （n=16）， Radix Lindera group （n=10），Jin Ling-zi powder group （n=20） and Xiao Huo-luo Dan group （n=7），respectively. Four days after the CCI surgery，the drugs were given by intragastric administration. The rats in Corydalis Yanhusuo group，Radix Lindera group，Jin Ling-zi powder group and Xiao Huo-luo Dan group were given 12 g·kg-1 drug respectively. The sham operation group and saline group were given the same amount of saline. The rats were administered intragastrically once a day for 14 consecutive days. From the beginning of the administration，the threshold of thermal pain was measured every other day by hot needling instrument. Results：Compared with Control group，the thermal threshold of Corydalis Yanhusuo group，Radix Lindera group，Jin Ling-zi powder group and Xiao Huo-luo Dan group were all increased，but the increase of Corydalis Yanhusuo group and Jin Ling-zi powder group were more significantly. Conclusion：Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan all have analgesic effect on neuropathic pain，among which Jin Ling-zi powder has the strongest analgesic effect and the

fastest curative effect，followed by Corydalis Yanhusuo. The analgesic effects of Radix Lindera and Xiao Huo-luo Dan were not stable.

Key words:Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder,Xiao Huo-luo Dan,neuropathic pain,analgesia

JIAO Miao-miao, WANG Xu, ZHOU Na, ZHANG Meng, LIU Jin-na, TAN Zhan-wang, HUANG Dong-yang. Comparison of Analgesic Effects of Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan on Rats with Neuropathic Pain#br#[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(2): 1-.

References

[1]María Dueñas, Begoña Ojeda, Alejandro Salazar,et al. A review of chronic pain impact on patients, their social environment and the health care system[J]．J Pain Res, 2016, 9: 457-467.

[2] van Hecke O，Austin S K，Khan R A，et al. Neuropathic pain in the general population: A systematic review of epidemiological studies[J]．Pain, 2014, 155(4) : 654-662．

[3]房铭铭,刘红权.神经病理性疼痛中西医诊疗的相关问题[J].中国临床医生杂志,2020,48(04):388-391.

[4]Nanna B Finnerup, Nadine Attal, Simon Haroutounian,et al.Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis[J]. Lancet Neurology, 2015, 14(2): 162-173.

[5]吴志伟,宋朋飞,朱清广,等.神经病理性疼痛机制研究进展[J].河北医科大学学报,2018,39(09):1095-1100.

[6]王楠,顾梦佳,余娟娟,等.中医镇痛理论发展及基于支持度分析的镇痛方剂用药规律探索[J].四川中医,2018,36(01):40-42.

[7]武亚茹,常可欣,贾庆忠.神经病理性疼痛动物模型的制备与评价方法[J].神经药理学报,2017，7(05):15-20.

[8]廖尖兵,刘淼,王文譞,等.探微慢性疼痛中医病、机、证、治思路[J].中华中医药杂志,2018,33(04):1441-1444.

[9]国家药典委员会.中华人民共和国药典．一部[S]．北京:中国医药科技出版社，2015: 139．

[10]关秀锋,王锐,曲秀芬,等.延胡索的化学成分与药理作用研究进展[J].化学工程师,2020,34(03):57-60.

[11]杨建明,曹亮,薛贵平,等.高效液相色谱法测定中药延胡索炮制前后延胡索乙素的含量[J].欧宝平台登录学报：医学版,2010,27(06):13-15.

[12]邢梦雨,田崇梅,夏道宗.乌药化学成分及药理作用研究进展[J].天然产物研究与开发,2017,29(12):2147-2151.

[13]桓娜,于俊生,刘玉萍.乌药的中药学及临床应用文献综述[J].中国中医药现代远程教育,2017,15(09):148-150.

[14]张剑,罗人仕,杨瑜,等.乌药总生物碱抗炎镇痛药理学研究[J].中国医院药学杂志,2016,36(24):2187-2190.

[15]沈淑洁,刘少磊,黄荣清,等.金铃子散最新研究进展[J].中医药导报,2016,22(08):111-113.

[16]王翠芳.金铃子散及其拆方抗炎镇痛的代谢组学研究[D].广州：广东药科大学,2019.

[17]钟丹.小活络丹加味联合阿片类止痛药治疗前列腺癌骨转移疼痛寒湿痹阻证的临床观察[D].长沙：湖南中医药大学,2018.

[18]蒋爱品,王庆军.小活络丸药理及临床应用研究新进展[J].北京中医药,2009,28(02):148-150.

[19]杨波,纪宏宇,郑东友,等.中药延胡索的炮制工艺和药理作用的研究进展[J].药学实践杂志,2017,35(02):112-115，153.

[20]李景松.延胡索镇痛镇静作用研究概况[C]. 中国商品学会中药商品专业委员会.第三届中国中药商品学术年会暨首届中药葛根国际产业发展研讨会论文集.中国商品学会中药商品专业委员会:中国商品学会,2012:191-193.

[21]郑雅,王博龙,邹盛勤.金铃子散作用机制的网络药理学分析[J].中药新药与临床药理,2019,30(10):1211-1221.

[22] 李珊,陈文明,欧阳荣.乌药及其炮制品不同提取物镇痛作用的研究[J].中国现代应用药学,2015,32(11):1306-1308.

[23]何素梅.古方在痹症中的临床应用体会[J].中国处方药,2020,18(01):115-116.

[24]宋佳男,于海波,刘玉梅.神经病理性疼痛的治疗和药物发现现状[J/OL].药学报:1-21[2020-11-11].https://doi.org/10.16438/j.0513-4870.2020-1131.

[25]苏静.加巴喷丁联合羟考酮缓释片治疗癌性神经病理性疼痛患者的临床疗效[J].现代诊断与治疗,2020,31(12):1881-1882.

[26]李黎,张海林.CCL2/CCR2参与神经病理性疼痛的多靶点作用机制[J].神经药理学报,2016,6(01):49-57.

[27]郭杨.普瑞巴林对神经病理性疼痛大鼠脊髓TRPV1通道蛋白的影响[D].泸州：西南医科大学,2019.

[28]李泓锡,姚鹏.普瑞巴林在神经病理性疼痛中应用的研究进展[J].中国医师进修杂志,2019(01):81-84.

[29]齐维.升降散加味治疗神经病理性疼痛的实验研究及临床应用[D].广州：广州中医药大学,2016.

[30]王翠芳,杨建云,肖炳坤,等.复方中药金铃子散及其单味药镇痛抗炎作用的比较[J].科学技术与工程,2018,18(24):209-212.

[31]王俊丽,赵闻平,兰云,等.金铃子散汤剂与散剂药效学的比较研究[J].西北国防医学杂志,2013,34(04):345-346.

[32]成龙,王岚,王彦礼,等.金铃子散不同配比方对大鼠肝药酶CYP1A2活性的影响[J].中国中药杂志,2012,37(05):648-653.

[33]汪群红,胡敏,汪官富.乌药生物碱镇痛和抗炎作用研究[J].中华中医药学刊,2015,33(04):910-912.

[34]李太极.小活络丹加味对大鼠实验性膝骨性关节炎血清中IL-1β、TNF-α、MMP-3的影响[D].郑州：河南中医药大学,2016.