ACTA NEUROPHARMACOLOGICA››2020,Vol. 10››Issue (3): 42-46.DOI:10.3969/j.issn.2095-1396.2020.03.008

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Research Progress of Danggui Shaoyao Powder in Improving Cognitive Function

SUN Yi,HOU Xue-qin,WANG Fu-gang

  1. Shandong First Medical University & Shandong Academy of Medical Sciences,Taian,271016,China
  • Online:2020-06-26Published:2021-05-14
  • Contact:侯雪芹,硕士生导师;E-mail:xqhou@tsmc.edu.cn
  • About author:孙逸,药理学硕士研究生;E-mail:syzzbqzl@163.com
  • Supported by:
    山东省中医药管理局项目(No.2019-0361);山东省医药卫生科技发展计划项目(No. 2018WS130);山东省高等学校科技计划项目(No. J17KA250)

Abstract:

Danggui Shaoyao San is an ancient recipe of Chinese medicine recorded in Jingui Yaolue by Zhang Zhong-jing in Han Dynasty. It was created for“ women with pregnancy”,“women with various diseases and pains in the abdomen. It is a famous prescription for strengthening spleen and clearing damp,nourishing blood and regulating liver. Danggui Shaoyao San has a neuroprotective effect. Its mechanism of action is mainly related to regulation of estrogen level,inhibition of oxidative stress,neuronal synapses and other transduction pathways and related signal molecules. Therefore,Danggui Shaoyao San may be used as a potential treatment for Alzheimer’s disease and other central neurodegenerative diseases. pharmacological effects and mechanism of Danggui Shaoyao San will be described. Danggui Shaoyao San,as well as the latest research on the effects,would be paid more and more attention. In this paper,the chemical constituents and pharmacological effects of Danggui Shaoyao San were reviewed.

Key words:Danggui Shaoyao San,cognitive function,pharmacological,clinical application

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