Objective：To analyze the effect of routine and optimized treatment in ICU on cerebral resuscitation in patients with post-cardiac arrest syndrome. Methods：Ninety patients with post-cardiac arrest syndrome were selected as the subjects of this study. The period of patients’ visits was from July 2018 to November 2019.They were divided into two groups according to the order of admission treatment. Among them，45 patients who received routine treatment in ICU were set as the control group，and another 45 patients who received optimized treatment in ICU were included in the observation group. The neurological scores，clinical indicators and complication rates of the two groups of patients with post-cardiac arrest syndrome were compared. Results：After treatment，the improvement of neurological function and clinical indicators in the observation group was significantly better than that in the control group；the incidence of complications in the observation group was 4.4%；the incidence of complications in the control group was 17.8%. There were significant differences in neurological function scores，clinical indicators and complication rates between the two groups of patients with postcardiac arrest syndrome （P<0.05）. Conclusion：Compared with conventional treatment in ICU，ICU optimized treatment has more significant clinical effect on patients with post-cardiac arrest syndrome，can promote the improvement of patients’ cerebral resuscitation，improve the efficiency of neurological recovery，improve cardiac function indicators，reduce the occurrence of complications，and improve the quality of life of patients with syndrome，and has positive promotion value.