Progress on the Relationship between Pathogenic Microorganisms and Alzheimer’s Disease

Abstract

Abstract:

Alzheimer’s disease（ AD），a cerebral disease，accounts for the majority of senile dementia that affects the health of the old. Although many theories on AD pathogenesis have been proposed，so far，there are no effective treatments to restrict its development. Recently “infection hypothesis” of AD have shown that a variety of pathogenic microorganism can directly penetrate

the blood-brain barrier （BBB），reach the brain，cause inflammatory reactions，and damage neurons. The most common pathogens through BBB are herpes simplex virus，Cytomegalovirus，Chlamydia pneumoniae，Spirochetes，Helicobacter pylori，Porphyromonas gingivalis，Fungus. In this article，we mainly discussed the potential role of pathogenic microorganisms in the etiologyand progression of AD，expounded the relationship between pathogens and AD，which would provide theoretical basis for the pathogenesis，prevention and treatment of AD.

Key words:Alzheimer’s disease,bacteria,virus,fungi,inflammation,infection

CLC Number:

R965

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HAI Ji-tao, LUO Huan-min. Progress on the Relationship between Pathogenic Microorganisms and Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(4): 58-64.

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URL:http://actanp.hebeinu.edu.cn/EN/10.3969/j.issn.2095-1396.2020.04.010

http://actanp.hebeinu.edu.cn/EN/Y2020/V10/I4/58

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