Objective：To analyze the changes of emotion，cognitive function and inflammatory state in patients with post-ischemic stroke depression （PISD） after treatment with butylphthalide and sertraline. Methods：126 PISD patients who met the screening criteria were randomly divided into control group and experimental group. Sertraline and butylphenylpeptide combined with sertraline were used to treat PISD patients，and the inflammation status and inflammation status of the two groups were compared and analyzed. Results：Before treatment，there was no significant difference in neurological function，depressive state，cognitive function and HPA axis function between the two groups in PISD patients.After treatment，the neurological function，depressive state，cognitive status and HPA axis function of the two groups were improved. Compared with the control group，the NIHSS and Hamilton Depression Scale（HAMD） scores of the experimental group were lower，while the MMSE scores were significantly higher. The HAMD score was low while the Mental Status Assessment Scale （MMSE） score was significantly high. The levels of serum corticotropin releasing hormone （CRH），corticotropin（ACTH） and cortisol （Cor） in the experimental group were significantly lower than those in the control group. Compared with the control group，hs-CRP，TNF-alpha，IL-8 in the experimental group were significantly lower （ P<0.05）. Compared with the control group，the total number of

patients cured in the experimental group was 60 （95.2%），which was significantly higher than that in the control group，and the difference between the two groups was significant （ P<0.05）. Compared with the control group，the experimental group had significantly higher scores in four aspects of physical health，mental health，social function and material life. Conclusion：

Butylphthalide combined with sertraline can effectively improve the level of inflammatory factors in PISD patients，improve HPA axis function，improve cognitive function，and reduce the severity of mental injury and depression.