Migraine is a recurrent chronic neurovascular headache. It is one of the common primary headache in clinic. It affects patients’ daily life and work to a great extent，hinders the development of social productivity and brings huge economic burden to individuals and society. At present，a large number of studies at home and abroad have found that migraine is related to right-to-left shunt （RLS），but the specific principle is still under study. Studies have shown that the incidence of white matter lesions （WML） in migraine patients is three times higher than that in normal people，and its pathophysiological mechanism has not been clarified. The results of recent studies suggest that the prevalence of patent foramen ovale （PFO） in migraine patients was significantly higher than that in normal people，especially migraine with aura （MA）. Whether there is a relationship between white matter lesions and right to left shunt in migraine patients， and the pathophysiological mechanisms between them are not clear，which is worthy of further study.