Hypertension is one of the most common cardiovascular and cerebrovascular diseases in the world，and its understanding has gradually penetrated into the fields of centra and inflammatory factors. Under the same living conditions，which groups are more likely to induce hypertension and the mechanism of its induction have become the most important research direction in the primary prevention of hypertension. Generation of a high-fat diet during pregnancy and lactation，can raise the offspring of central nervous system related to blood pressure，increase high blood pressure，central sensitivity，adults are more likely to form the epigenetic metabolic syndrome，compared with other groups in exposure to the risk factors of sympathetic activation，such as high fat，high salt，high sugar intake，and so on and so forth，are more likely to appear blood pressure of adverse reactions. This article reviews the mechanism and significance of central sensitization of hypertension in early life.