ACTA NEUROPHARMACOLOGICA››2022,Vol. 12››Issue (2): 53-.DOI:10.3969/j.issn.2095-1396.2022.02.010

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Study on the Influencing Factors and Related Mechanisms of Dyskinesia in Parkinson’s Disease

DONG Lu-lu,WANG Lu-lu,CHEN Jing-hong,et al

  1. 1 Hebei North University,Zhangjiakou,075000,China 2 North China University of Science and Technology,Tangshan,063210,China 3 Hebei General Hospital,Shijiazhuang,050051,China
  • Online:2022-04-26Published:2022-04-26

Abstract:

Long-term administration of levodopa to restore dopamine levels in the brain has long been the gold standard treatment for Parkinson’s disease (PD). Levodopa supplementation improves the motor symptoms of PD,but the effect of long-term medication on levodopa-induced dyskinesias (LID) is still a controversial and urgent problem to be solved clinically. At present,there are different analyses on the risk factors of LID caused by levodopa, and many factors affect each other. This article will review the incidence and influencing factors of PD dyskinesia,so as to avoid intervention of risk factors in the process of diagnosis and treatment,prevent and reduce the occurrence of LID as early as possible.

Key words:Parkinson’s disease,dyskinesia,mechanism

CLC Number:

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