Type 2 diabetes is a genetically predisposed endocrine metabolic disease caused by multiple factors. The disease is widespread worldwide and seriously endangers human health. At present，the pathogenesis of modern medicine for this disease has not been fully understood， clinical treatment of this disease is mostly to enhance the sensitivity of islet β cells or promote insulin secretion to stabilize glucose，including diet exercise therapy，oral hypoglycemic drug therapy，insulin therapy and so on. Traditional medicine believes that type 2 diabetes belongs to the category of Xiaoke，the disease is located in the lungs，stomach and kidneys，and its basic disease mechanism is yin deficiency internal dry heat，and the system of triple Xiao is adopted when dialectics. However，with the rapid development of the times and the changes in the lifestyle of modern people，the existing treatment methods of traditional Chinese and Western medicine have been unable to meet the needs of clinical type 2 diabetes patients in an all-round and multi-level manner，so it is imperative to seek safe and efficient treatment. Whether from the perspective of basic theory，molecular mechanism，animal experiment or clinical research，there are unique advantages in the treatment of type 2 diabetes from the liver and spleen，which have gradually become a hot topic in today’s research. This article reviews the research progress of traditional Chinese and Western medicine in the treatment of type 2 diabetes from the liver and spleen，so as to provide new treatment ideas for the clinical treatment of type 2 diabetes.