Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury

Abstract

Abstract:The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies，carried out at different levels，have confirmed that there are also preconditioning phenomenona in brain，and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning (CIP) can decrease cell apoptosis，increase the anti-oxidant ability and decrease oxidant injury，increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.

Key words:ischemia hypoxia preconditioning,apoptosis,reactive oxygen species,signal transduction,hypoxic inducible factor,heat shock proteins

CLC Number:

R743

YUAN Heng-jie，LOU Jian-shi. Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury[J]. Acta Neuropharmacologica, 2011, 1(4): 42-47.

References

1 Liu Yajun, Sercombe Richard, Xie Dongping,et al. Inhibition of Caspase-9 activation and apoptosis is involved in ischemic preconditioning-induced neuroprotection in rat brain[J]. Neurol Res, 2007, 29(8)：855-861.
2 Henrik Hagberg, Carina Mallard, Catherine I.Rousset,et al. Apoptotic mechanisms in the immature brain：involvement of mitochondria[J]. J Child Neurol, 2009, 24(9)：1141-1146.
3 Li Danqing，Bao Yongming，Li Yang，et al. Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury [J]. Brain Res, 2006, 1115(1)：179-185．
4 Rybnikova E, Sitnik N, Gluschenko T,et al. The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats[J]. Brain Res, 2006, 1089(1)：195-202.
5 Wang Guangsong, Zhou Deshan, Wang Changzheng,et al. Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons[J]. J Neurochem, 2010, 114(4)：1039-1048.
6 Racay P, Tatarkova Z, Drgova A,et al. Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats[J]. Neurochem Res, 2007, 32(11)：1823-1832.
7 Watters O, O'Connor JJ. A role for tumor necrosis factor-α in ischemia and ischemic preconditioning[J]. J Neuroinflammation, 2011, 8(2)：87.
8 Zhang Quanguang, Wang Ruimin，Han Dong，et al. Peconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk[J]. Neurosci Res, 2009, 63(3)：205-212
9 Wang Ruiming，Zhang Quanguang，Li Jie，et al. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats[J]. Brain Res, 2009, 1255（19）：32-41.
10 Du Y, Li C, Hu WW,et al. Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways[J].Neuroscience, 2009, 161(2)：370-380.
11 李永旺，金海龙，王保国，等. Toll样受体4信号通路在缺氧预处理诱导的大鼠脑缺血耐受中的作用[J].中华医学杂志, 2007, 87(35)：2458-2462.
12 Alkan T, Gören B, Vatansever E,et al. Effects of hypoxic preconditioning in antioxidant enzyme activities in hypoxic-ischemic brain damage in immature rats [J]. Turk Neurosurg, 2008, 18(2)：165-171.
13 Yuan Hengjie, Zhu Xuehui, Luo Qiong,et al. Noninvasive delayed limb ischemic preconditioning in rats increases antioxidant activities in cerebral tissue during severe ischemia-reperfusion injury[J]. J Surg Res, 2012, 174(1)：176-183.
14 Racay P, Chomova M, Tatarkova Z,et al. Ischemia-induced mitochondrial apoptosis is significantly attenuated by ischemic preconditioning[J].Cell Mol Neurobiol, 2009, 29(6-7)：901-908.
15 Sonia C.Correia, Cristina Carvalho, Susana Cardoso,et al. Mitochondrial preconditioning：a potential neuroprotective strategy[J]. Front Aging Neurosci, 2010, 2：138.
16 Ulrich Dirnagl, Andreas Meisel. Endogenous neuroprotection：mitochondria as gateways to cerebral preconditioning[J].Neuropharmacology, 2008, 55(3)：334–344.
17 Hansson MJ, Morota S, Teilum M,et al.Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume[J].J Biol Chem, 2010, 285(1)：741-750.
18 Jou MJ. Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes[J]. Adv Drug Deliv Rev, 2008, 60(13-14)：1512–1526.
19 Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia：from experimental strategies to clinical use[J]. Lancet Neurol, 2009, 8(4)：398-412.
20 Simerabet Malika, Robin Emmanuel, Aristi Ines,et al. Preconditioning by an in situ administration of hydrogen peroxide：involvement of reactive oxygen species and mitochondrial ATP-dependent potassium channel in a cerebral ischemia-reperfusion model[J]. Brain Res, 2008, 1240：177-184.
21 Rehni AK, Shri R, Singh M. Remote ischaemic preconditioning and prevention of cerebral injury[J]. Indian J Exp Biol, 2007, 45(3)：247-252.
22 Miyawaki Takahiro, Mashiko Toshihiro, Ofengeim Dimmitry,et al. Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons[J].Proc Natl Acad Sci USA, 2008, 105(12)：4892-4897.
23 Lin HY, Wu CL, Huang CC. The Akt-endothelial nitric oxide synthase pathway in lipopolysaccharide preconditioning-induced hypoxic-ischemic tolerance in the neonatal rat brain[J]. Stroke, 2010, 41(7)：1543-1551.
24 Zhan Lixuan, Wang Tao, Li Wen,et al. Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats[J].J Neurochem, 2010, 114(3)：897-908.
25 Wang Ruimin, Zhang Quanguang, Li Jie,et al. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats[J]. Brain Res, 2009, 1255：32-41.
26 Sawe N, Steinberg G, Zhao H. Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke[J]. J Neurosci Res, 2008, 6(8)：1659-1669.
27 Yang Chengwei, Ren Yongxin, Liu Feng,et al. Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3 dissociation[J]. Neurosci Lett, 2008, 441(3)：267-271.
28 Li Liyuan, Chikezie O.Madu, Andrew Lu,et al. HIF-1α Promotes A Hypoxia-Independent Cell Migration[J]. Open Biol J, 2010, 3(1)：8-14.
29 Hare GM, Tsui AK, McLaren AT,et al. Anemia and cerebral outcomes：many questions，fewer answers[J]. Anesth Analg, 2008, 107(4)：1356-1370.
30 Peng Z, Ren P, Kang Z,et al. Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning[J]. Brain Res, 2008, 1212：71-78.
31 Christian Grimm, A Wenzel, N Acar,et al. Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration [J]. Adv Exp Med Biol, 2006, 588：119-131.
32 Ara J, Fekete S, Frank M,et al. Hypoxic-preconditioning induces neuroprotection against hypoxia-ischemia in newborn piglet brain[J]. Neurobiol Dis, 2011, 43(2)：473-485.
33 Gao CJ, Niu L, Ren PC,et al. Hypoxic preconditioning attenuates global cerebral ischemic injury following asphyxial cardiac arrest through regulation of delta opioid receptor system[J]. Neuroscience, 2012, 202：352-362.
34 Müller BA, Naranjan S Dhalla. Mechanisms of the beneficial actions of ischemic preconditioning on subcellular remodeling in ischemic-reperfused heart[J]. Curr Cardiol Rev, 2010, 6(4)：255-164.
35 蒋淑君，张楠，李俊发. cPKCγ-HSP60信号通路参与小鼠脑低氧预适应[J].中国病理生理杂志, 2011, 27（6）：1066-1070.
36 卢娜, 李晓娟, 李成长, 等.低氧预适应对大鼠缺血-再灌注性脑损伤中HSP-70、Survivin蛋白和学习记忆能力的影响[J].南方医科大学学报，2007，27(12)：1856-1860.
37 Sun XC, Xian XH, Li WB,et al. Activation of p38 MAPK participates in brain ischemic tolerance induced by limb ischemic preconditioning by up-regulating HSP 70[J]. Exp Neurol, 2010, 224(2)：347-355.
38 袁恒杰，罗琼，朱学慧，等.无创性延迟肢体预适应对大鼠脑缺血再灌注皮层的保护作用[J].中国临床药理与治疗学，2009，14(2)：144-149.

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